ArticleInvestigative ophthalmology & visual science2013
Accommodative movements of the vitreous membrane, choroid, and sclera in young and presbyopic human and nonhuman primate eyes.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 98 citations in OpenAlex.
- Effects of Atropine Treatment on Choroidal Thickness in Myopic Children.Investigative ophthalmology & visual science · 2020Trial
- Presbyopia: Current Perspectives and Prospects for Patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Ciliary Zonule of the Human Eye: Structural and Mechanical Aspects.Investigative ophthalmology & visual science · 2026Article
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
- Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques.Drug delivery · 2025Article
- Ciliary muscle traction during accommodation is able to induce optic nerve head deformation.Eye (London, England) · 2025Article
- Anatomic Relationship Among Descemet's Membrane, Trabecular Meshwork, Scleral Spur, and Ciliary Muscle.Investigative ophthalmology & visual science · 2025Article
- Choroidal thickness under pilocarpine versus cyclopentolate.Scientific reports · 2025Article
- Quantification of the Anterior-Centripetal Movement of the Ciliary Muscle During Accommodation Using Dynamic OCT Imaging.Translational vision science & technology · 2025Article
- Comparative morphological analysis of the zonular apparatus in porcine, feline, and canine species.Frontiers in medicine · 2025Article
- Association between ocular diseases and screen time and sedentary time derived from job-exposure matrices.Scientific reports · 2024Article
- The Mirror Theory: Parallels between Open Angle and Angle Closure Glaucoma.Life (Basel, Switzerland) · 2024Review
- Model of zonular forces on the lens capsule during accommodation.Scientific reports · 2024Article
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- Novel Discoveries of the Relationship Between the Vitreous Zonule and the Anterior Segment Characteristics in Eyes With Primary Angle-Closure Disease.Investigative ophthalmology & visual science · 2022Article
- Improvement in Accommodation and Dynamic Range of Focus After Laser Scleral Microporation: A Potential Treatment for Presbyopia.Translational vision science & technology · 2022Article
- Intraocular accommodative movements in monkeys; relationship to presbyopia.Experimental eye research · 2022Article
- Accommodative movements of the choroid in the optic nerve head region of human eyes, and their relationship to the lens.Experimental eye research · 2022Article
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6 authors at 2 institutions in 2 countries.
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Abstract
purposeWe report, for the first time to our knowledge, dynamic movements of the vitreous membrane and peripheral choroid during accommodation, and age-related changes in the anterior sclera.
methodsWe studied 11 rhesus monkeys (ages 6-27 years) and 12 human subjects (ages 19-65 years). Accommodation was induced pharmacologically in human subjects and by central electrical stimulation in the monkeys. Ultrasound biomicroscopy, endoscopy, and contrast agents were used to image various intraocular structures.
resultsIn the monkey, the anterior hyaloid membrane bows backward during accommodation in proportion to accommodative amplitude and lens thickening. A cleft exists between the pars plicata region and the anterior hyaloid membrane, and the cleft width increases during accommodation from 0.79 ± 0.01 mm to 1.01 ± 0.02 mm in young eyes (n = 2, P < 0.005), as fluid from the anterior chamber flows around the lens equator toward the cleft. In the older eyes the cleft width was 0.30 ± 0.19 mm, which during accommodation increased to 0.45 ± 0.20 mm (n = 2). During accommodation the ciliary muscle moved forward by approximately 1.0 mm, pulling forward the choroid, retina, vitreous zonule, and the neighboring vitreous interconnected with the vitreous zonule. Among the humans, in the older eyes the scleral contour bowed inward in the region of the limbus, compared to the young eyes.
conclusionsThe monkey anterior hyaloid bends posteriorly during accommodation in proportion to accommodative amplitude and the sclera bows inward with increasing age in both species. Future descriptions of the accommodative mechanism, and approaches to presbyopia therapy, may need to incorporate these findings.
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