ArticleJournal of the American Society of Nephrology : JASN2013
Temporal trends in fracture rates and postdischarge outcomes among hemodialysis patients.
Article in Journal of the American Society of Nephrology : JASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- A Systematic Review and Meta-analysis of the Association Between Vitamin K Antagonist Use and Fracture.Journal of general internal medicine · 2019Pooled it
- Effects of Cinacalcet on Fracture Events in Patients Receiving Hemodialysis: The EVOLVE Trial.Journal of the American Society of Nephrology : JASN · 2015Trial
- Article
- Emerging treatments and current strategies for mineral, vascular, and bone disorders in chronic kidney disease.World journal of nephrology · 2026Review
- Relationship of lumbar vertebral volumetric bone mineral density with trunk muscle density assessed by quantitative computed tomography in maintenance hemodialysis patients.Renal failure · 2025Article
- Cemented versus cementless hemiarthroplasty in end-stage chronic kidney disease: A retrospective comparative study of femoral neck fracture outcomes.Acta orthopaedica et traumatologica turcica · 2025Article
- Orthopaedic fracture site and wound healing risk among end-stage renal disease patients undergoing open reduction internal fixation: A database analysis.Journal of clinical orthopaedics and trauma · 2025Article
- Higher Serum Alkaline Phosphatase Is a Risk Factor of Death and Fracture: A Nationwide Cohort Study of Japanese Patients on Dialysis.Kidney360 · 2025Article
- Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients.Clinical kidney journal · 2025Article
- Review
- Magnesium and Fracture Risk in the General Population and Patients Receiving Dialysis: A Narrative Review.Canadian journal of kidney health and disease · 2023Review
- Bone Disease in Chronic Kidney Disease and Kidney Transplant.Nutrients · 2022Review
- Article
- Kidney Transplantation, Immunosuppression and the Risk of Fracture: Clinical and Economic Implications.Kidney medicine · 2022Article
- Prevalence and predictors of asymptomatic vertebral fracture in patients with end-stage renal disease.Heliyon · 2022Article
- The Role of DMP1 in CKD-MBD.Current osteoporosis reports · 2021Review
- Bone Fragility Fractures in CKD Patients.Calcified tissue international · 2021Review
- Fractures and their sequelae in non-dialysis-dependent chronic kidney disease: the Stockholm CREAtinine Measurement project.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Observational
- Long-term excess mortality after hip fracture in hemodialysis patients: a nationwide cohort study in Japan.Journal of bone and mineral metabolism · 2020Article
- Transcriptomics: a Solution for Renal Osteodystrophy?Current osteoporosis reports · 2020Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Patients with ESRD have a substantially increased risk of bone fractures, but the burden of fractures has not been sufficiently characterized in this population. Here, we analyzed fracture rates and postdischarge outcomes using Medicare data from hemodialysis patients in the United States between 2000 and 2009. We assessed adjusted quarterly fracture rates (inpatient and outpatient) and consequences of postfracture hospitalization for seven categories of fracture location. Pelvis/hip, vertebral, and lower leg fractures were the most prevalent fracture types. Pelvis/hip fractures declined slightly from 29.6 to 20.6 per 1000 patient-years between early 2000 and late 2009, but the incidence rates for all other fracture types remained relatively constant. Median lengths of stay for the primary fracture hospitalization ranged from 5 days (interquartile range [IQR], 3-9 days) for forearm/wrist fractures to 8 days (IQR, 5-12 days) for femur fractures. The proportion of patients discharged from the primary hospitalization to a skilled-nursing facility ranged from 28% (ribs/sternum) to 47% (pelvis/hip). A negative binomial regression model suggested that patients had an adjusted mean of 3.8-5.2 additional hospitalizations during the year after discharge from the index hospitalization, varying by fracture type, comprising a mean of 33-52 inpatient days. Case-mix-adjusted mortality rates after discharge ranged from 0.43 to 0.91 per patient-year and were highest for vertebral, pelvis/hip, and femur fractures. In conclusion, fractures in the dialysis population are common and are associated with a substantially increased risk for death and hospitalization.
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