Trial reportBlood2013
Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation.
Trial report in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00760656 (Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Trial
- Randomized trial of radiation-free central nervous system prophylaxis comparing intrathecal triple therapy with liposomal cytarabine in acute lymphoblastic leukemia.Haematologica · 2015Trial
- Trial
- Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.Pediatric blood & cancer · 2014Trial
- Temporal mapping of radiation-induced neural injury and mitigation in human cortical organoids.Stem cells translational medicine · 2026Article
- The therapeutic role of ginseng in promoting hippocampal neurogenesis and ameliorating cognitive function following whole brain radiotherapy in rats.Metabolic brain disease · 2025Article
- Article
- Socio-economic outcomes among long-term childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC CLG studies: Results of the 58LAE study.European journal of cancer care · 2022Article
- A narrative review of the late effects of paediatric cancer treatment within an educational setting: Existing evidence and where do we go from here?Chronic illness · 2022Review
- Prophylactic Central Nervous System Irradiation Is Not Indispensable in Adult Patients with Acute Lymphoblastic Leukemia: A Multicenter Retrospective Cohort StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2022Article
- Long-term neurocognitive and quality of life outcomes in survivors of pediatric hematopoietic cell transplant.Journal of cancer survivorship : research and practice · 2022Article
- Article
- Late health effects and changes in lifestyle factors after cancer in childhood with and without subsequent second primary cancers - the KiKme case-control study.Frontiers in oncology · 2022Article
- Aging in Adult Survivors of Childhood Cancer: Implications for Future Care.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Towards new long-term composite 'Quality of Survival' endpoints.Bone marrow transplantation · 2020Article
- Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats.Radiation oncology (London, England) · 2020Article
- Alcohol consumption behaviors and neurocognitive dysfunction and emotional distress in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.Addiction (Abingdon, England) · 2019Article
- Article
- A Cross-sectional Study of Two Chemotherapy Protocols on Long Term Neurocognitive Functions in Egyptian Children Surviving Acute Lymphoblastic Leukemia.Current pediatric reviews · 2018Article
- Chronic hepatitis C virus infection and neurocognitive function in adult survivors of childhood cancer.Cancer · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy (CRT) are at risk for cognitive impairment, although whether impairment progresses with age into adulthood is unknown. We report change in intelligence for 102 adult survivors of childhood ALL (age range, 26.6-54.7 years) during a median interval of 28.5 years. Survivors demonstrated lower Performance intelligence (mean, 95.3; standard deviation, 16.5; P = .005) but not Verbal IQ (mean, 97.4; standard deviation, 15.44; P = .09) at initial testing. Verbal intelligence declined an average of 10.3 points (P < .0001) during the follow-up interval with no decline in Performance intelligence. Decline was associated with current attention problems (P = .002) but not gender, CRT dose, age at CRT exposure, or years between testing. Results suggest long-term survivors of childhood ALL treated with CRT are at risk for progressive decline in verbal intellect, which may be driven by attention deficits. This trial was registered at clinicaltrials.gov as no. NCT00760656.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.