Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
Does hormone replacement normalize bone geometry in adolescents with anorexia nervosa?
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00310791 (Effects of Adrenal and Gonadal Hormone Replacement in Young Women With Anorexia Nervosa), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Adrenal and Gonadal Hormone Replacement in Young Women With Anorexia Nervosa
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Anorexia nervosa and adrenal hormones: a systematic review and meta-analysis.European journal of endocrinology · 2023Pooled it
- Pharmacological treatment options for low Bone Mineral Density and secondary osteoporosis in Anorexia Nervosa: A systematic review of the literature.Journal of psychosomatic research · 2017Pooled it
- Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa.The Journal of clinical endocrinology and metabolism · 2021Trial
- Oestrogen replacement improves bone mineral density in oligo-amenorrhoeic athletes: a randomised clinical trial.British journal of sports medicine · 2019Trial
- Trial
- Therapeutic approaches for endocrine dysregulation in anorexia nervosa in adolescents.Frontiers in pediatrics · 2026Review
- Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Hypothalamic-pituitary-adrenal axis in anorexia nervosa; an underestimated endocrine dysfunction among adolescents.Frontiers in pediatrics · 2024Review
- Advances in Diagnosis and Management of Childhood OsteoporosisJournal of clinical research in pediatric endocrinology · 2022Review
- Psychiatric and medical comorbidities of eating disorders: findings from a rapid review of the literature.Journal of eating disorders · 2022Review
- Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- Hormonal Contraception and Bone Health in Adolescents.Frontiers in endocrinology · 2020Review
- Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment.Journal of bone metabolism · 2019Review
- Low bone mineral density in anorexia nervosa: Treatments and challenges.Clinical reviews in bone and mineral metabolism · 2019Article
- Impact of Route of Estrogen Administration on Bone Turnover Markers in Oligoamenorrheic Athletes and Its Mediators.The Journal of clinical endocrinology and metabolism · 2019Article
- Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews.Journal of clinical medicine · 2019Review
- Effects of Anorexia Nervosa on Bone Metabolism.Endocrine reviews · 2018Review
- Article
- Eating disorders and bone metabolism in women.Current opinion in pediatrics · 2017Review
- Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women.Calcified tissue international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Young women with anorexia nervosa (AN) have reduced secretion of dehydroepiandrosterone (DHEA) and estrogen contributing to skeletal deficits. In this randomized, placebo-controlled trial, we investigated the effects of oral DHEA + combined oral contraceptive (COC) versus placebo on changes in bone geometry in young women with AN. Eighty women with AN, aged 13 to 27 years, received a random, double-blinded assignment to micronized DHEA (50 mg/day) + COC (20 µg ethinyl estradiol/0.1 mg levonorgestrel) or placebo for 18 months. Measurements of areal bone mineral density (aBMD) at the total hip were obtained by dual-energy X-ray absorptiometry at 0, 6, 12, and 18 months. We used the Hip Structural Analysis (HSA) program to determine BMD, cross-sectional area (CSA), and section modulus at the femoral neck and shaft. Each measurement was expressed as a percentage of the age-, height-, and lean mass-specific mean from an independent sample of healthy adolescent females. Over the 18 months, DHEA + COC led to stabilization in femoral shaft BMD (0.0 ± 0.5% of normal mean for age, height, and lean mass/year) compared with decreases in the placebo group (-1.1 ± 0.5% per year, p = 0.03). Similarly, CSA, section modulus, and cortical thickness improved with treatment. In young women with AN, adrenal and gonadal hormone replacement improved bone health and increased cross-sectional geometry. Our results indicate that this combination treatment has a beneficial impact on surrogate measures of bone strength, and not only bone density, in young women with AN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.