ArticleCell death & disease2013
Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Evasion of cell death despite mitochondrial outer membrane permeabilization: an oncogenic outcome of apoptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Antimycobacterial and Anticancer Properties ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion.EMBO reports · 2021Article
- Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis.PLoS computational biology · 2020Article
- Inhibition of cyclinB1 Suppressed the Proliferation, Invasion, and Epithelial Mesenchymal Transition of Hepatocellular Carcinoma Cells and Enhanced the Sensitivity to TRAIL-Induced Apoptosis.OncoTargets and therapy · 2020Article
- Article
- TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis.Life science alliance · 2019Article
- Article
- A single-cell micro-trench platform for automatic monitoring of cell division and apoptosis after chemotherapeutic drug administration.Scientific reports · 2018Article
- Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer.Oncotarget · 2018Article
- An Antimicrobial Peptide InducesFrontiers in microbiology · 2018Article
- cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition.Oncotarget · 2017Article
- N-terminal gelsolin fragment potentiates TRAIL mediated death in resistant hepatoma cells.Scientific reports · 2017Article
- Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells.Oncotarget · 2017Article
- Article
- Inhibitor of apoptosis proteins as intracellular signaling intermediates.The FEBS journal · 2016Review
- Nanoparticle-Mediated Target Delivery of TRAIL as Gene Therapy for Glioblastoma.Advanced healthcare materials · 2015Article
- Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.Oncotarget · 2015Article
- Effects of curine in HL-60 leukemic cells: cell cycle arrest and apoptosis induction.Journal of natural medicines · 2015Article
- Plasmodium infection reduces the volume of the viral reservoir in SIV-infected rhesus macaques receiving antiretroviral therapy.Retrovirology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting tumor cells represent a huge challenge during anticancer therapy due to their increased treatment resistance. TNF-related apoptosis-inducing ligand (TRAIL) is a putative future anticancer drug, currently in phases I and II clinical studies. We recently showed that TRAIL is able to target leukemia stem cell surrogates. Here, we tested the ability of TRAIL to target cell cycle-arrested tumor cells. Cell cycle arrest was induced in tumor cell lines and xenografted tumor cells in G0, G1 or G2 using cytotoxic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Biochemical or molecular arrest at any point of the cell cycle increased TRAIL-induced apoptosis. Accordingly, when cell cycle arrest was disabled by addition of caffeine, the antitumor activity of TRAIL was reduced. Most important for clinical translation, tumor cells from three children with B precursor or T cell acute lymphoblastic leukemia showed increased TRAIL-induced apoptosis upon knockdown of either cyclinB or cyclinE, arresting the cell cycle in G2 or G1, respectively. Taken together and in contrast to most conventional cytotoxic drugs, TRAIL exerts enhanced antitumor activity against cell cycle-arrested tumor cells. Therefore, TRAIL might represent an interesting drug to treat static-tumor disease, for example, during minimal residual disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.