ArticleProceedings of the National Academy of Sciences of the United States of America2013
Evolutionarily conserved Wolbachia-encoded factors control pattern of stem-cell niche tropism in Drosophila ovaries and favor infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 107 citations in OpenAlex.
- Cappable-Seq reveals the transcriptional landscape of stress responses in the bacterial endosymbiontMicrobial genomics · 2025Article
- Symbiotic Bacteria: Wolbachia, Midgut Microbiota in Mosquitoes and Their Importance for Vector Prevention Strategies.Microbial ecology · 2024Review
- The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells.PLoS pathogens · 2024Article
- Complete de novo assembly of Wolbachia endosymbiont of Drosophila willistoni using long-read genome sequencing.Scientific reports · 2024Article
- Mixed Wolbachia infections resolve rapidly during in vitro evolution.PLoS pathogens · 2024Article
- Complete de novo assembly ofResearch square · 2024Article
- MixedbioRxiv : the preprint server for biology · 2024Article
- Evidence of horizontal transmission ofFrontiers in insect science · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The cellular lives of Wolbachia.Nature reviews. Microbiology · 2023Review
- Wolbachia endosymbionts manipulate the self-renewal and differentiation of germline stem cells to reinforce fertility of their fruit fly host.PLoS biology · 2023Article
- Distinct Wolbachia localization patterns in oocytes of diverse host species reveal multiple strategies of maternal transmission.Genetics · 2023Article
- UsingFrontiers in microbiology · 2023Review
- Symbionts on the Brain: HowmBio · 2022Article
- Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.Parasites & vectors · 2022Article
- Comparative genome sequencing reveals insights into the dynamics of Wolbachia in native and invasive cherry fruit flies.Molecular ecology · 2021Article
- Comparative Genomics Reveals Factors Associated with Phenotypic Expression of Wolbachia.Genome biology and evolution · 2021Article
- Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer.PLoS pathogens · 2020Article
- Tissue Tropisms and Transstadial Transmission of aApplied and environmental microbiology · 2020Article
- Signal transduction in the early Drosophila follicle stem cell lineage.Current opinion in insect science · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Wolbachia are intracellular bacteria that infect invertebrates at pandemic levels, including insect vectors of devastating infectious diseases. Although Wolbachia are providing novel strategies for the control of several human pathogens, the processes underlying Wolbachia's successful propagation within and across species remain elusive. Wolbachia are mainly vertically transmitted; however, there is also evidence of extensive horizontal transmission. Here, we provide several lines of evidence supporting Wolbachia's targeting of ovarian stem cell niches--referred to as "niche tropism"--as a previously overlooked strategy for Wolbachia thriving in nature. Niche tropism is pervasive in Wolbachia infecting the Drosophila genus, and different patterns of niche tropism are evolutionarily conserved. Phylogenetic analysis, confirmed by hybrid introgression and transinfection experiments, demonstrates that bacterial factors are the major determinants of differential patterns of niche tropism. Furthermore, bacterial load is increased in germ-line cells passing through infected niches, supporting previous suggestions of a contribution of Wolbachia from stem-cell niches toward vertical transmission. These results support the role of stem-cell niches as a key component for the spreading of Wolbachia in the Drosophila genus and provide mechanistic insights into this unique tissue tropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.