ArticleBrazilian journal of otorhinolaryngology
The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?Clinical and experimental otorhinolaryngology · 2019Article
- FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity.International journal of molecular medicine · 2017Article
- An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats.Clinical and experimental otorhinolaryngology · 2015Article
- Sensorineural deafness following routine transurethral resection of the prostate.BMJ case reports · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHyperbaric oxygen therapy (HBOT) has enhanced the prevention and treatment of auditory ailments such as ototoxicity.
objectiveTo study the effects of HBOT upon ototoxic injuries produced by amikacin.
methodThis experimental study included 12 albino guinea pigs, whose auditory function was assessed through distortion product otoacoustic emissions (DPOAEs) and brainstem auditory evoked potentials (BAEPs) before and after the administration of amikacin (600 mg/kg/day) and HBOT sessions (2 ATA, 60 minutes). Morphological features were analyzed through scanning electron microscopy. Subjects were divided into four groups, as follows: group 1 - saline solution + HBOT; group 2 - amikacin for 8 days; group 3 - amikacin + seven days of rest; and group 4 - amikacin + HBOT.
resultsGroup 1 subjects had preserved function and morphology throughout the experiment; Group 2 subjects had statistically significant levels of hair cell injury and functional impairment; Subjects on groups 3 and 4 had statistically significant functional and morphological impairment after the administration of amikacin, which were still present after the proposed procedures had been carried out.
conclusionHyperbaric oxygen therapy did not change the cochlear hair cell morphology or the electro-physiological thresholds of the guinea pigs given amikacin.
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