ReviewCurrent opinion in gastroenterology2013
Epigenetics: the fine-tuner in inflammatory bowel disease?
Review in Current opinion in gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- T cell and cytokine signatures as early predictors of response to IL-12/IL-23 inhibition in Crohn's disease.Frontiers in immunology · 2026Article
- Histone acylations as a mechanism for regulation of intestinal epithelial cells.Digestive medicine research · 2024Article
- Article
- The Synergistic Effects of 5-Aminosalicylic Acid and Vorinostat in the Treatment of Ulcerative Colitis.Frontiers in pharmacology · 2021Article
- Epigenetics of chronic inflammatory diseases.Journal of inflammation research · 2019Review
- Determinants of IBD Heritability: Genes, Bugs, and More.Inflammatory bowel diseases · 2018Review
- The HDAC Inhibitor, SAHA, Prevents Colonic Inflammation by Suppressing Pro-inflammatory Cytokines and Chemokines in DSS-induced Colitis.Acta histochemica et cytochemica · 2018Article
- Recent Advances in the Etiopathogenesis of Inflammatory Bowel Disease: The Role of Omics.Molecular diagnosis & therapy · 2018Review
- A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.PloS one · 2018Article
- Neonatal immune challenge followed by adult immune challenge induces epigenetic-susceptibility to aggravated visceral hypersensitivity.Neurogastroenterology and motility · 2017Article
- Influence of environmental factors in the development of inflammatory bowel diseases.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis.Clinical epigenetics · 2016Article
- Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives.World journal of gastroenterology · 2015Review
- DNA methylation profile of genes involved in inflammation and autoimmunity in inflammatory bowel disease.Medicine · 2014Article
- The histone deacetylase Hdac1 regulates inflammatory signalling in intestinal epithelial cells.Journal of inflammation (London, England) · 2014Article
- Mucosal healing and deep remission: what does it mean?World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewEpigenetic studies are transforming our understanding of a variety of complex pathological conditions including cancer, autoimmune, and inflammatory diseases. A selection of the major recent advances in this area will be reviewed, focusing on the important emerging themes that are relevant to these diseases including inflammatory bowel disease (IBD). RECENT
findingsThe main current themes that will be addressed on the role of epigenetics in disease pathogenesis include current understanding of the nature and function of histone modifications and DNA methylation; the connection between epigenetics and metabolic pathways; new studies on the mechanism of heritability of epigenetic changes; the role of stochastic noise and the expanding research on chromatin readers and their potential as selective therapeutic targets. The recent contribution of epigenetic modifications in defining the molecular basis of IBD and how such changes may act as fine-tuners of gene expression in these intestinal disorders are also discussed. SUMMARY: Published evidence over the last 12-18 months indicates that targeting epigenetic factors can be efficacious in cancer and inflammatory disease. All the indications are that future research will continue to reveal new epigenetic targets and mechanisms that will advance the prospects for selective epigenetic therapy for IBD and other complex diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.