ArticleScientific reports2013
How many Orai's does it take to make a CRAC channel?
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity.Cell communication and signaling : CCS · 2026Review
- Review
- p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization.American journal of physiology. Cell physiology · 2023Article
- ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets.Pharmaceuticals (Basel, Switzerland) · 2023Review
- ORAI1 CaFrontiers in cell and developmental biology · 2021Review
- Store-Operated Calcium Entry in the Cardiovascular System.Advances in experimental medicine and biology · 2021Review
- Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry.Cell calcium · 2019Review
- Molecular understanding of calcium permeation through the open Orai channel.PLoS biology · 2019Article
- Detecting In-Situ oligomerization of engineered STIM1 proteins by diffraction-limited optical imaging.PloS one · 2019Article
- ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain.The Journal of physiology · 2019Article
- Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor.The Journal of biological chemistry · 2018Article
- The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization.Frontiers in bioscience (Landmark edition) · 2018Article
- The Orai1 Store-operated Calcium Channel Functions as a Hexamer.The Journal of biological chemistry · 2016Article
- Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.Biophysical journal · 2016Article
- α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.Molecular biology of the cell · 2016Article
- Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.Biophysical journal · 2015Article
- Store-Operated Calcium Channels.Physiological reviews · 2015Review
- From GTP and G proteins to TRPC channels: a personal account.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.Cell research · 2015Article
- Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message.Science signaling · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CRAC (Calcium Release-Activated Calcium) channels represent the primary pathway for so-called "store-operated calcium entry" - the cellular entry of calcium induced by depletion of intracellular calcium stores. These channels play a key role in diverse cellular activities, most noticeably in the differentiation and activation of Tcells, and in the response of mast cells to inflammatory signals. CRAC channels are formed by members of the recently discovered Orai protein family, with previous studies indicating that the functional channel is formed by a tetramer of Orai subunits. However, a recent report has shown that crystals obtained from the purified Drosophila Orai protein display a hexameric channel structure. Here, by comparing the biophysical properties of concatenated hexameric and tetrameric human Orai1 channels expressed in HEK293 cells, we show that the tetrameric channel displays the highly calcium-selective conductance properties consistent with endogenous CRAC channels, whilst the hexameric construct forms an essentially non-selective cation channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.