Evidence map›Paper›PMID 23743512›Full record

ReviewCurrent opinion in allergy and clinical immunology2013

Tick bites and red meat allergy.

Scott P Commins, Thomas A E Platts-Mills

Abstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 132 citations in OpenAlex.

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  10. IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.The Journal of allergy and clinical immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Scott P ComminsDepartment of Internal Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia 22908, USA. scottcommins@virginia.edu
Thomas A E Platts-Mills
University of Virginia Health System · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAR01AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLATTS-MILLS, THOMAS A. · 1985 to 2017
$7.1M
Mechanisms of airways pH deviation in asthma and chronic coughU19AI070364 · NIAID · UNIVERSITY OF VIRGINIA · PI PLATTS-MILLS, THOMAS A. · 2006 to 2010
$6.0M
IgE to carbohydrates causes delayed anaphylaxisK08AI085190 · NIAID · UNIVERSITY OF VIRGINIA · PI COMMINS, SCOTT PALMER · 2010 to 2014
$651k
Delayed anaphylaxis to beef and pork: mechanisms and causes of a new food allergyR21AI087985 · NIAID · UNIVERSITY OF VIRGINIA · PI COMMINS, SCOTT PALMER, PLATTS-MILLS, THOMAS A. · 2010 to 2011
$422k
NIAID NIH HHS K08 AI085190NIAID NIH HHS K08-AI-1085190NIAID NIH HHS R01 AI020565NIAID NIH HHS R01-AI-20565NIAID NIH HHS R21 AI087985NIAID NIH HHS R21-AI-087985NIAID NIH HHS T32 AI007496NIAID NIH HHS U19 AI070364NIAID NIH HHS U19-AI-070364
6 · The paper itself

Abstract

purpose of reviewA novel form of anaphylaxis has been described that is due to IgE antibody (Ab) directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). Ongoing work regarding the cause and distribution of this IgE response is reviewed. RECENT

findingsOur recent work has identified a novel IgE Ab response that has been associated with two distinct forms of anaphylaxis: immediate-onset anaphylaxis during first exposure to intravenous cetuximab and delayed-onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g. beef and pork). Further studies strongly suggested that tick bites were a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the United States and internationally. SUMMARY: Large numbers of patients with IgE Ab to alpha-gal continue to be identified in the USA and globally. Clinicians should be aware of this IgE response as the reactions often appear to be idiopathic because of the significant delay between eating mammalian meat and the appearance of symptoms.

Indexed as

MeatAnaphylaxisAnimalsDisaccharidasesEpitopesFood HypersensitivityHumansImmunoglobulin ETick BitesUnited StatesDisaccharidasesEpitopesImmunoglobulin E

Identifiers

PMID23743512
PMCPMC4235259
OpenAlexW2060929865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.