ArticleUltrasound in medicine & biology2013
Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz.
Article in Ultrasound in medicine & biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Comparative effects of focused ultrasound and microbubbles on healthy and tumor bearing rat spinal cord.Scientific reports · 2025Article
- Theranostics in the vasculature: bioeffects of ultrasound and microbubbles to induce vascular shutdown.Theranostics · 2023Review
- Intravital imaging and cavitation monitoring of antivascular ultrasound in tumor microvasculature.Theranostics · 2023Article
- Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.Advanced drug delivery reviews · 2022Review
- Sonodynamic Therapy for the Treatment of Intracranial Gliomas.Journal of clinical medicine · 2021Review
- A High-Frequency Phased Array System for Transcranial Ultrasound Delivery in Small Animals.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Ultrafast three-dimensional microbubble imagingTheranostics · 2020Article
- Intracranial Non-thermal Ablation Mediated by Transcranial Focused Ultrasound and Phase-Shift Nanoemulsions.Ultrasound in medicine & biology · 2019Article
- Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control.Scientific reports · 2018Article
- Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening.Theranostics · 2018Article
- Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range.Physics in medicine and biology · 2017Article
- Nonthermal ablation in the rat brain using focused ultrasound and an ultrasound contrast agent: long-term effects.Journal of neurosurgery · 2016Article
- Cavitation-enhanced nonthermal ablation in deep brain targets: feasibility in a large animal model.Journal of neurosurgery · 2016Article
- Nonthermal ablation of deep brain targets: A simulation study on a large animal model.Medical physics · 2016Article
- Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections.Medical physics · 2015Article
- Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Low-intensity focused ultrasound was applied with microbubbles (Definity, Lantheus Medical Imaging, North Billerica, MA, USA; 0.02 mL/kg) to produce brain lesions in 50 rats at 558 kHz. Burst sonications (burst length: 10 ms; pulse repetition frequency: 1 Hz; total exposure: 5 min; acoustic power: 0.47-1.3 W) generated ischemic or hemorrhagic lesions at the focal volume revealed by both magnetic resonance imaging and histology. Shorter burst time (2 ms) or shorter sonication time (1 min) reduced the probability of lesion production. Longer pulses (200 ms, 500 ms and continuous wave) caused significant near-field damage. Using microbubbles with focused ultrasound significantly reduced acoustic power levels and, therefore, avoided skull heating issues and potentially can extend the treatable volume of transcranial focused ultrasound to brain tissues close to the skull.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.