ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2013
Serum creatinine level, a surrogate of muscle mass, predicts mortality in peritoneal dialysis patients.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Pooled it
- Liraglutide reduces the body weight and waist circumference in Chinese overweight and obese type 2 diabetic patients.Acta pharmacologica Sinica · 2015Trial
- Circulating 20S proteasome is independently associated with abdominal muscle mass in hemodialysis patients.PloS one · 2015Trial
- The Obesity Paradox Reconsidered: Evidence from a Multicenter Romanian Hemodialysis Cohort.Journal of clinical medicine · 2026Article
- Association between the serum uric acid-to-creatinine ratio and cardiovascular mortality in maintenance hemodialysis patients.Renal failure · 2025Article
- Pretransplant Serum Creatinine in Peritoneal Dialysis Patients Predicts Graft Outcomes.Kidney medicine · 2025Article
- Pharmacological HIF-PH Inhibition Suppresses Myoblast Differentiation Through Continued HIF-1α Stabilization.International journal of molecular sciences · 2025Article
- Variations in Creatinine Generation Among Patients With Glomerular Disease: Evidence From the NEPTUNE and CureGN Studies.Kidney medicine · 2025Article
- Novel evidence of arsenic-related excess adiposity and its implication in the risk of cardiometabolic diseases.Environmental research · 2025Article
- Comprehensive Insights into Sarcopenia in Dialysis Patients: Mechanisms, Assessment, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2025Review
- Prediction Models for Risk of Cardiorespiratory Morbidity/Mortality and Fracture Among Young Adults With Cerebral Palsy.Journal of cachexia, sarcopenia and muscle · 2025Article
- Survival of Continuous Ambulatory Peritoneal Dialysis Patients Increases in the Early Years of Dialysis: Comparison of Parametric Frailty Survival Models.Advanced biomedical research · 2025Article
- Creatinine, cystatin C, muscle mass, and mortality: Findings from a primary and replication population-based cohort.Journal of cachexia, sarcopenia and muscle · 2024Article
- Cystatin C and sarcopenia index are associated with cardiovascular and all-cause death among adults in the United States.BMC public health · 2024Article
- Combination of Creatinine with Inflammatory Biomarkers (PCT, CRP, hsCRP) for Predicting Postoperative ICU Admissions for Elderly Patients.Advances in therapy · 2024Article
- Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients.International journal of molecular sciences · 2024Article
- Mortality prediction with adaptive feature importance recalibration for peritoneal dialysis patients.Patterns (New York, N.Y.) · 2023Article
- A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis.Journal of clinical medicine · 2023Article
- Transcriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis.Scientific reports · 2023Article
- Article
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundIn hemodialysis patients, higher serum creatinine (Cr) concentration represents larger muscle mass and predicts greater survival. However, this association remains uncertain in peritoneal dialysis (PD) patients.
methodsIn a cohort of 10 896 PD patients enrolled from 1 July 2001 to 30 June 2006, the association of baseline serum Cr level and change during the first 3 months after enrollment with all-cause mortality was examined.
resultsThe cohort mean ± SD age was 55 ± 15 years old and included 52% women, 24% African-Americans and 48% diabetics. Compared with patients with serum Cr levels of 8.0-9.9 mg/dL, patients with serum Cr levels of <4.0 mg/dL and 4.0-5.9 mg/dL had higher risks of death {HR 1.36 [95% confidence interval (95% CI) 1.19-1.55] and 1.19 (1.08-1.31), respectively} whereas patients with serum Cr levels of 10.0-11.9 mg/dL, 12.0-13.9 mg/dL and ≥14.0 mg/dL had lower risks of death (HR 0.88 [95% CI 0.79-0.97], 0.71 [0.62-0.81] and 0.64 [0.55-0.75], respectively) in the fully adjusted model. Decrease in serum Cr level over 1.0 mg/dL during the 3 months predicted an increased risk of death additionally. The serum Cr-mortality association was robust in patients with PD treatment duration of ≥12 months, but was not observed in those with PD duration of <3 months.
conclusionsMuscle mass reflected in serum Cr level may be associated with survival even in PD patients. However, the serum Cr-mortality association is attenuated in the early period of PD treatment, suggesting competing effect of muscle mass versus residual renal function on mortality.
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