ArticleCNS neuroscience & therapeutics2013
Six-month ischemic mice show sensorimotor and cognitive deficits associated with brain atrophy and axonal disorganization.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
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- Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration.NPJ Regenerative medicine · 2024Article
- Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat - A multimodal and comprehensive model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Long-term structural brain changes in adult rats after mild ischaemic stroke.Brain communications · 2022Article
- Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury.Brain communications · 2022Article
- Longitudinal hippocampal volumetric changes in mice following brain infarction.Scientific reports · 2021Article
- In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery.Acta neuropathologica communications · 2021Article
- The Relationship between Cerebral White Matter Integrity and Cognitive Function in Mild Stroke with Basal Ganglia Region Infarcts.Scientific reports · 2018Article
- Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury.Experimental neurology · 2018Article
- Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice.Scientific reports · 2017Article
- Internalization of nanopolymeric tracers does not alter characteristics of placental cells.Journal of cellular and molecular medicine · 2016Article
- Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury.CNS neuroscience & therapeutics · 2016Article
- Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Article
- Cellular correlates of longitudinal diffusion tensor imaging of axonal degeneration following hypoxic-ischemic cerebral infarction in neonatal rats.NeuroImage. Clinical · 2014Article
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsTo identify long-term sensorimotor and cognitive deficits and to evaluate structural alterations in brain ischemic mice.
methodsC57Bl/6J male mice were subjected to 30 min transient middle cerebral artery occlusion (tMCAo) or sham surgery. Sensorimotor deficits, exploratory behavior, and cognitive functions were evaluated up to 6 months. Cortical and subcortical damage were analyzed by MRI multiparameter analysis and histopathology.
resultstMCAo mice showed significant sensorimotor deficits in the rotarod, negative geotaxis, neuroscore, and beam walk tests. They also showed impairment in exploratory behavior in the open field test and in spatial learning in the Morris water maze. T2-weighted MRI revealed a volume reduction in injured brain areas at 12 and 24 weeks postinjury. Brain atrophy was shown by MRI and conventional postmortem analysis. Diffusion tensor imaging on the external capsule showed increased values of axial and radial diffusivity. Fiber tracking revealed a reduction in the number and length of ipsilateral fibers.
conclusionstMCAo in mice induces sensorimotor and cognitive impairments detectable at least up to 6 months postinjury, associated with brain atrophy, and axonal and myelin damage of the external capsule. These behavioral tests and anatomical investigations may represent important tools in translational studies in cerebral ischemia.
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