ArticleActa ophthalmologica2013
Impaired retinal vasodilator responses in prediabetes and type 2 diabetes.
Article in Acta ophthalmologica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population-based studies.Diabetes, obesity & metabolism · 2025Article
- Advances in Structural and Functional Retinal Imaging and Biomarkers for Early Detection of Diabetic Retinopathy.Biomedicines · 2024Review
- Pros and cons of live kidney donation in prediabetics: A critical review and way forward.World journal of transplantation · 2024Review
- Microvascular and Endothelial Dysfunction in Prediabetes.Life (Basel, Switzerland) · 2023Review
- Addressing the Continuum of Dysglycaemia and Vascular Complications in Prediabetes and Type 2 Diabetes: Need for Early and Intensive Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Risk Factors for the Development of Retinopathy in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Experience.Diabetes care · 2022Article
- A stronger association of diabetes mellitus with impaired hyperaemia using a novel ECG-gated device compared with peripheral arterial tonometry.International ophthalmology · 2022Article
- Are disease-related symptoms important to predicting developing diabetes from prediabetes?Turkish journal of medical sciences · 2022Article
- Retinal Protein O-GlcNAcylation and the Ocular Renin-angiotensin System: Signaling Cross-roads in Diabetic Retinopathy.Current diabetes reviews · 2022Article
- Diabetes mellitus associated neurovascular lesions in the retina and brain: A review.Frontiers in ophthalmology · 2022Review
- Neuro-vascular coupling and heart rate variability in patients with type II diabetes at different stages of diabetic retinopathy.Frontiers in medicine · 2022Article
- Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study.Frontiers in medicine · 2021Article
- Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy.Journal of clinical medicine · 2020Article
- Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain-retina-heart link: the SABPA study.Eye (London, England) · 2020Article
- Emerging Insights and Interventions for Diabetic Retinopathy.Current diabetes reports · 2019Review
- Assessing the prevalence and risk factors of pre-diabetes among the community of Iganga municipality, Uganda: a cross sectional study.BMC research notes · 2019Article
- Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Retinal vessel diameters and reactivity in diabetes mellitus and/or cardiovascular disease.Cardiovascular diabetology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeIn diabetes, endothelial dysfunction and subsequent structural damage to blood vessels can lead to heart attacks, retinopathy and strokes. However, it is unclear whether prediabetic subjects exhibit microvascular dysfunction indicating early stages of arteriosclerosis and vascular risk. The purpose of this study was to examine whether retinal reactivity may be impaired early in the hyperglycaemic continuum and may be associated with markers of inflammation.
methodsIndividuals with prediabetes (n = 22), type 2 diabetes (n = 25) and healthy age and body composition matched controls (n = 19) were studied. We used the Dynamic Vessel Analyzer to assess retinal vasoreactivity (percentage change in vessel diameter) during a flickering light stimulation. Fasting highly sensitive c-reactive protein (hs-CRP), a marker of inflammation, was measured in blood plasma.
resultsPrediabetic and diabetic individuals had attenuated peak vasodilator and relative amplitude changes in retinal vein diameters to the flickering light stimulus compared with healthy controls (peak dilation: prediabetic subjects 3.3 ± 1.8%, diabetic subjects 3.3 ± 2.1% and controls 5.6 ± 2.6%, p = 0.001; relative amplitude: prediabetic subjects 4.3 ± 2.2%, diabetic subjects 5.0 ± 2.6% and control subjects 7.2 ± 3.2%, p = 0.003). Similar findings were observed in retinal arteries. Levels of hs-CRP were not associated with either retinal vessel response parameters.
conclusionRetinal reactivity was impaired in prediabetic and type 2 diabetic individuals in parallel with reduced insulin sensitivity but not associated with levels of hs-CRP. Retinal vasoreactivity measurements may be a sensitive tool to assess early vascular risk.
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