ArticleBMC complementary and alternative medicine2013
Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hepatoprotective effects of blue honeysuckle on CClFood science & nutrition · 2019Article
- Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes.International journal of molecular sciences · 2018Article
- Polymethoxyflavones fromFrontiers in pharmacology · 2018Article
- Expression of glutathione S-transferase A1, a phase II drug-metabolizing enzyme in acute hepatic injury on mice.Experimental and therapeutic medicine · 2017Article
- Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice.BMC complementary and alternative medicine · 2016Article
- In vitro anti oxidant activity and acute oral toxicity of Terminalia paniculata bark ethanolic extract on Sprague Dawley rats.Asian Pacific journal of tropical biomedicine · 2014Article
- Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.BioMed research international · 2014Article
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Authors and funding
8 authors.
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Abstract
backgroundBased on the reported antioxidant and anti-inflammatory potential of Terminalia paniculata, the bark aqueous extract (TPW) was investigated against liver damage.
methodsIntrinsic cytotoxicity was tested on normal human liver (Chang) cell lines, followed by acute and sub-chronic toxicity studies in mice. TPW was then evaluated against CCl4-induced liver toxicity in rats. Liver enzymes (AST, ALT, and ALP) and antioxidant markers were assessed. The effect of TPW on isolated hepatic cells, post-CCl4 administration, was assessed by isolated mitochondrial membrane staining. The actions of TPW on apoptotic pathway in CCl4-treated Chang cells were also elucidated.
resultsTPW was found to be safe at all doses tested in both in vitro and in vivo toxicity studies. TPW (400 mg/kg, p.o.) significantly (*p <0.05) improved liver enzyme activity as compared to CCl4. Also, it improved antioxidant status (GSH, GST, MDA and total thiol) and preserved hepatic cell architecture. TPW pre-treatment significantly attenuated the levels of phospho-p53, p53, cleaved caspase-3, phospho-Bad, Bad and cleaved PARP in CCl4-treated Chang cells, improving the viability considerably.
conclusionThe findings support a protective role for Terminalia paniculata in pathologies involving oxidative stress.
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