ArticleMolecular pharmaceutics2013
Disulfide cross-linked phosphorylcholine micelles for triggered release of camptothecin.
Article in Molecular pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 76 citations in OpenAlex.
- Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines.Pharmaceutics · 2022Article
- Camptothesome Potentiates PD-L1 Immune Checkpoint Blockade for Improved Metastatic Triple-Negative Breast Cancer Immunochemotherapy.Molecular pharmaceutics · 2022Article
- Immunogenic Nanovesicle-Tandem-Augmented Chemoimmunotherapy via Efficient Cancer-Homing Delivery and Optimized Ordinal-Interval Regime.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Redox-Responsive Nanocarrier for Controlled Release of Drugs in Inflammatory Skin Diseases.Pharmaceutics · 2020Article
- Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases.Advanced functional materials · 2020Article
- Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery.Acta biomaterialia · 2020Review
- Thermally Assisted Generation of Protein-Poly(ethylene sodium phosphate) Conjugates with High Mineral Affinity.ACS omega · 2019Article
- Polymer-Temozolomide Conjugates as Therapeutics for Treating Glioblastoma.Molecular pharmaceutics · 2018Article
- Article
- Antifouling Stripes Prepared from Clickable Zwitterionic Copolymers.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery.Macromolecular bioscience · 2017Review
- Novel delivery approaches for cancer therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin.Biomaterials · 2015Article
- Structure-redox-relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes.Inorganic chemistry · 2014Article
- Reduction-responsive polymeric micelles and vesicles for triggered intracellular drug release.Antioxidants & redox signaling · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A series of block copolymers based on 2-methacryloyloxyethyl phosphorylcholine (MPC) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Incorporation of dihydrolipoic acid (DHLA) into the hydrophobic block led to formation of block copolymer micelles in water. The micelles were between 15 and 30 nm in diameter, as characterized by dynamic light scattering (DLS), with some size control achieved by adjusting the hydrophobic/hydrophilic balance. Cross-linked micelles were prepared by disulfide formation, and observed to be stable in solution for weeks. The micelles proved amenable to disassembly when treated with a reducing agent, such as dithiothreitol (DTT), and represent a potential delivery platform for chemotherapeutic agents. As a proof-of-concept, camptothecin (CPT) was conjugated to the polymer scaffold through a disulfide linkage, and release of the drug from the micelle was monitored by fluorescence spectroscopy. These CPT-loaded prodrug micelles showed a reduction in release rate compared to physically encapsulated CPT. The use of disulfide conjugation facilitated drug release under reducing conditions, with a half-life (t1/2) of 5.5 h in the presence of 3 mM DTT, compared to 28 h in PBS. The toxicity of the micellar prodrugs was evaluated in cell culture against human breast (MCF7) and colorectal (COLO205) cancer cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.