ArticlePloS one2013
Interactions between the R2R3-MYB transcription factor, AtMYB61, and target DNA binding sites.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Phytoplasma Effector SJP8 Suppresses Host Immunity by Promoting the Degradation of ZjMYB15 and ZjMYB86-like to Perturb Jasmonic Acid and Hydrogen Peroxide Homeostasis in Jujube.Molecular plant pathology · 2026Article
- Biosynthesis and Regulatory Mechanisms of Plant Flavonoids: A Review.Plants (Basel, Switzerland) · 2025Review
- AaMYB121, a Novel R2-MYB-like Transcription Factor, Regulates Artemisinin Biosynthesis inInternational journal of molecular sciences · 2025Article
- Lignin biosynthesis pathway repressors in gymnosperms: differential repressor domains as compared to angiosperms.Forestry research · 2024Review
- Distinct guard cell-specific remodeling of chromatin accessibility during abscisic acid- and COProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptomic response of Pinus massoniana to infection stress from the pine wood nematode Bursaphelenchus xylophilus.Stress biology · 2023Article
- Distinct guard cell specific remodeling of chromatin accessibility during abscisic acid and CObioRxiv : the preprint server for biology · 2023Article
- CC-type glutaredoxin, MeGRXC3, associates with catalases and negatively regulates drought tolerance in cassava (Manihot esculenta Crantz).Plant biotechnology journal · 2022Article
- Genome-Wide Prediction of Transcription Start Sites in Conifers.International journal of molecular sciences · 2022Article
- Identification of candidate MYB transcription factors that influenceFrontiers in plant science · 2022Article
- Mining genes associated with furanocoumarin biosynthesis in an endangered medicinal plant,Journal of genetics · 2020Article
- Ectopic Overexpression of a Novel R2R3-MYB, NtMYB2 from Chinese Narcissus Represses Anthocyanin Biosynthesis in Tobacco.Molecules (Basel, Switzerland) · 2018Article
- Identification and Characterization of the Diverse Stress-ResponsiveInternational journal of genomics · 2017Article
- BjMYB1, a transcription factor implicated in plant defence through activating BjCHI1 chitinase expression by binding to a W-box-like element.Journal of experimental botany · 2016Article
- Stress-MediatedFrontiers in plant science · 2016Review
- The Arabidopsis MYB96 Transcription Factor Is a Positive Regulator of ABSCISIC ACID-INSENSITIVE4 in the Control of Seed Germination.Plant physiology · 2015Article
- Functional Analysis of a Pomegranate (Iranian journal of biotechnology · 2015Article
- Analysis of the DNA-Binding Activities of the Arabidopsis R2R3-MYB Transcription Factor Family by One-Hybrid Experiments in Yeast.PloS one · 2015Article
- Ternary WD40 Repeat-Containing Protein Complexes: Evolution, Composition and Roles in Plant Immunity.Frontiers in plant science · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the prominent roles played by R2R3-MYB transcription factors in the regulation of plant gene expression, little is known about the details of how these proteins interact with their DNA targets. For example, while Arabidopsis thaliana R2R3-MYB protein AtMYB61 is known to alter transcript abundance of a specific set of target genes, little is known about the specific DNA sequences to which AtMYB61 binds. To address this gap in knowledge, DNA sequences bound by AtMYB61 were identified using cyclic amplification and selection of targets (CASTing). The DNA targets identified using this approach corresponded to AC elements, sequences enriched in adenosine and cytosine nucleotides. The preferred target sequence that bound with the greatest affinity to AtMYB61 recombinant protein was ACCTAC, the AC-I element. Mutational analyses based on the AC-I element showed that ACC nucleotides in the AC-I element served as the core recognition motif, critical for AtMYB61 binding. Molecular modelling predicted interactions between AtMYB61 amino acid residues and corresponding nucleotides in the DNA targets. The affinity between AtMYB61 and specific target DNA sequences did not correlate with AtMYB61-driven transcriptional activation with each of the target sequences. CASTing-selected motifs were found in the regulatory regions of genes previously shown to be regulated by AtMYB61. Taken together, these findings are consistent with the hypothesis that AtMYB61 regulates transcription from specific cis-acting AC elements in vivo. The results shed light on the specifics of DNA binding by an important family of plant-specific transcriptional regulators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.