ArticlePloS one2013
Cocaine tolerance in honey bees.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Bees and pesticides: the research impact and scientometrics relations.Environmental science and pollution research international · 2021Review
- Cocaine Directly Impairs Memory Extinction and Alters Brain DNA Methylation Dynamics in Honey Bees.Frontiers in physiology · 2018Article
- Article
- Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions.Genes, brain, and behavior · 2017Article
- The Effects of Fat Body Tyramine Level on Gustatory Responsiveness of Honeybees (Frontiers in systems neuroscience · 2017Article
- Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera.Journal of visualized experiments : JoVE · 2016Article
- Physiology of reproductive worker honey bees (Apis mellifera): insights for the development of the worker caste.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Negative impact of manganese on honeybee foraging.Biology letters · 2015Article
- Differences in the phototaxis of pollen and nectar foraging honey bees are related to their octopamine brain titers.Frontiers in physiology · 2014Article
- Cocaine affects foraging behaviour and biogenic amine modulated behavioural reflexes in honey bees.PeerJ · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasingly invertebrates are being used to investigate the molecular and cellular effects of drugs of abuse to explore basic mechanisms of addiction. However, in mammals the principle factors contributing to addiction are long-term adaptive responses to repeated drug use. Here we examined whether adaptive responses to cocaine are also seen in invertebrates using the honey bee model system. Repeated topical treatment with a low dose of cocaine rendered bees resistant to the deleterious motor effects of a higher cocaine dose, indicating the development of physiological tolerance to cocaine in bees. Cocaine inhibits biogenic amine reuptake transporters, but neither acute nor repeated cocaine treatments caused measurable changes in levels of biogenic amines measured in whole bee brains. Our data show clear short and long-term behavioural responses of bees to cocaine administration, but caution that, despite the small size of the bee brain, measures of biogenic amines conducted at the whole-brain level may not reveal neurochemical effects of the drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.