ArticlePloS one2013
Time course of the cross-over effect of fatigue on the contralateral muscle after unilateral exercise.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Non-local Muscle Fatigue Effects on Muscle Strength, Power, and Endurance in Healthy Individuals: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Non-local Acute Passive Stretching Effects on Range of Motion in Healthy Adults: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- The Duration of Non-Local Muscle Fatigue Effects.Journal of sports science & medicine · 2024Trial
- Effects of Different Recovery Modalities on Delayed Onset Muscle Soreness, Recovery Perceptions, and Performance Following a Bout of High-Intensity Functional Training.International journal of environmental research and public health · 2023Trial
- Acute bouts of upper and lower body static and dynamic stretching increase non-local joint range of motion.European journal of applied physiology · 2016Trial
- The cross-over effects of unilateral resistance exercise in trained males and females.European journal of applied physiology · 2026Article
- Non-local Muscle Fatigue in Young and Middle-Aged Women following Fast-Paced Walking.International journal of exercise science · 2026Article
- The Effects of Varying Intensities of Unilateral Handgrip Fatigue on Bilateral Movement.Brain sciences · 2025Article
- Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults.GeroScience · 2025Article
- Article
- The Effect of a Mental Task Versus Unilateral Physical Fatigue on Non-Local Muscle Fatigue in Recreationally Active Young Adults.Journal of sports science & medicine · 2023Article
- Unilaterally Induced Quadriceps Fatigue during Sustained Submaximal Isometric Exercise Does Not Alter Contralateral Leg Extensor Performance.Journal of functional morphology and kinesiology · 2023Article
- Lack of Evidence for Crossover Fatigue with Plantar Flexor Muscles.Journal of sports science & medicine · 2022Article
- Immediate voluntary activation deficits following submaximal eccentric contractions of knee extensors are associated with alterations of the sense of movement.Scientific reports · 2022Article
- Compensatory control between the legs in automatic postural responses to stance perturbations under single-leg fatigue.Experimental brain research · 2021Article
- Transcutaneous electrical nerve stimulation improves fatigue performance of the treated and contralateral knee extensors.European journal of applied physiology · 2019Article
- Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Is the cross-over effect of a unilateral high-intensity leg extension influenced by the sex of the participants?Biology of sex differences · 2018Article
- Sex comparisons of non-local muscle fatigue in human elbow flexors and knee extensors.Journal of musculoskeletal & neuronal interactions · 2018Article
- Cortical voluntary activation testing methodology impacts central fatigue.European journal of applied physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the cross-over effect of muscle fatigue and its time course on the non-exercising contralateral limb (NEL) after unilateral fatiguing contractions of the ipsilateral exercising limb (EL). For this purpose, 15 males performed two bouts of 100-second maximal isometric knee extensions with the exercising limb, and neuromuscular function of both the EL and NEL was assessed before (PRE), after a first fatiguing exercise (MID) and after a second fatiguing exercise (POST). Maximal voluntary isometric torque production declined in the EL after the first bout of exercise (-9.6%; p<0.001) while in the NEL, the decrease occurred after the second bout of exercise (-10.6%; p<0.001). At MID, torque decline of the EL was strictly associated to an alteration of the mechanical twitch properties evoked by neurostimulation of the femoral nerve (i.e., peak twitch torque, maximal rate of twitch development). According to these markers, we suggest that peripheral fatigue occurred. At POST, after the second bout of exercise, the voluntary activation level of the knee extensor muscles was altered from PRE (-9.1%; p<0.001), indicating an overall central failure in both the EL and NEL. These findings indicate that two bouts of unilateral fatiguing exercise were needed to induce a cross-over effect of muscle fatigue on the non-exercising contralateral limb. Differential adjustments of the motor pathway (peripheral fatigue vs. central fatigue) might contribute to the respective torque decline in the EL and the NEL. Given that our unilateral fatiguing exercise induced immediate maximal torque reduction in the EL and postponed the loss of torque production in the NEL, it is also concluded that the time course of muscle fatigue differed between limbs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.