ArticlePloS one2013
Gating of long-term potentiation by nicotinic acetylcholine receptors at the cerebellum input stage.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
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- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.PLoS computational biology · 2023Article
- Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer.Biomedicines · 2022Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Review
- Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Article
- Functional Constructivism Approach to Multilevel Nature of Bio-Behavioral Diversity.Frontiers in psychiatry · 2021Review
- The Cerebellar Dopaminergic System.Frontiers in systems neuroscience · 2021Review
- Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage.Communications biology · 2020Article
- Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hyperexcitability and Hyperplasticity Disrupt Cerebellar Signal Transfer in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Long-Lasting Response Changes in Deep Cerebellar NucleiFrontiers in cellular neuroscience · 2019Article
- Nicotine modulates human brain plasticity via calcium-dependent mechanisms.The Journal of physiology · 2018Article
- Cerebellar Learning Properties Are Modulated by the CRF Receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Activation of the CREB/Frontiers in cellular neuroscience · 2017Article
- Asymmetries in Cerebellar Plasticity and Motor Learning.Cerebellum (London, England) · 2016Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain needs mechanisms able to correlate plastic changes with local circuit activity and internal functional states. At the cerebellum input stage, uncontrolled induction of long-term potentiation or depression (LTP or LTD) between mossy fibres and granule cells can saturate synaptic capacity and impair cerebellar functioning, which suggests that neuromodulators are required to gate plasticity processes. Cholinergic systems innervating the cerebellum are thought to enhance procedural learning and memory. Here we show that a specific subtype of acetylcholine receptors, the α7-nAChRs, are distributed both in cerebellar mossy fibre terminals and granule cell dendrites and contribute substantially to synaptic regulation. Selective α7-nAChR activation enhances the postsynaptic calcium increase, allowing weak mossy fibre bursts, which would otherwise cause LTD, to generate robust LTP. The local microperfusion of α7-nAChR agonists could also lead to in vivo switching of LTD to LTP following sensory stimulation of the whisker pad. In the cerebellar flocculus, α7-nAChR pharmacological activation impaired vestibulo-ocular-reflex adaptation, probably because LTP was saturated, preventing the fine adjustment of synaptic weights. These results show that gating mechanisms mediated by specific subtypes of nicotinic receptors are required to control the LTD/LTP balance at the mossy fibre-granule cell relay in order to regulate cerebellar plasticity and behavioural adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.