ArticlePloS one2013
Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Balanced contractility and adhesion drive polarization in a minimal elastic actomyosin network.PLoS computational biology · 2026Article
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- Computational models in directed cell migration.Frontiers in cell and developmental biology · 2026Review
- Durotaxis and extracellular matrix degradation promote the clustering of cancer cells.iScience · 2025Article
- Mesenchymal cell migration on one-dimensional micropatterns.Frontiers in cell and developmental biology · 2024Review
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- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- The crucial role of adhesion in the transmigration of active droplets through interstitial orifices.Nature communications · 2023Article
- Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells.PLoS computational biology · 2022Article
- Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.PLoS computational biology · 2022Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity.Biophysics and physicobiology · 2022Article
- 1D micro-nanopatterned integrin ligand surfaces for directed cell movement.Frontiers in cell and developmental biology · 2022Article
- Critical role of lipid membranes in polarization and migration of cells: a biophysical view.Biophysical reviews · 2021Review
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reversible elastic phase field approach and application to cell monolayers.The European physical journal. E, Soft matter · 2020Article
- Active inter-cellular forces in collective cell motility.Journal of the Royal Society, Interface · 2020Article
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Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Computational modeling of eukaryotic cells moving on substrates is an extraordinarily complex task: many physical processes, such as actin polymerization, action of motors, formation of adhesive contacts concomitant with both substrate deformation and recruitment of actin etc., as well as regulatory pathways are intertwined. Moreover, highly nontrivial cell responses emerge when the substrate becomes deformable and/or heterogeneous. Here we extended a computational model for motile cell fragments, based on an earlier developed phase field approach, to account for explicit dynamics of adhesion site formation, as well as for substrate compliance via an effective elastic spring. Our model displays steady motion vs. stick-slip transitions with concomitant shape oscillations as a function of the actin protrusion rate, the substrate stiffness, and the rates of adhesion. Implementing a step in the substrate's elastic modulus, as well as periodic patterned surfaces exemplified by alternating stripes of high and low adhesiveness, we were able to reproduce the correct motility modes and shape phenomenology found experimentally. We also predict the following nontrivial behavior: the direction of motion of cells can switch from parallel to perpendicular to the stripes as a function of both the adhesion strength and the width ratio of adhesive to non-adhesive stripes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.