ArticlePloS one2013
A continuum model of actin waves in Dictyostelium discoideum.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows.PLoS computational biology · 2021Article
- Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.PLoS computational biology · 2021Article
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- Cell-Substrate Patterns Driven by Curvature-Sensitive Actin Polymerization: Waves and Podosomes.Cells · 2020Article
- A calcium-mediated actin redistribution at egg activation in Drosophila.Molecular reproduction and development · 2020Article
- Thermodynamically consistent treatment of the growth of a biopolymer in the presence of a smooth obstacle interaction potential.Physical review. E · 2019Article
- Oscillatory Switches of Dorso-Ventral Polarity in Cells Confined between Two Surfaces.Biophysical journal · 2018Article
- A master equation approach to actin polymerization applied to endocytosis in yeast.PLoS computational biology · 2017Article
- Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles.Nature communications · 2017Article
- Adhesion-Dependent Wave Generation in Crawling Cells.Current biology : CB · 2017Article
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- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Modeling self-organized spatio-temporal patterns of PIP₃ and PTEN during spontaneous cell polarization.Physical biology · 2014Article
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- Eukaryotic Cell Dynamics from Crawlers to Swimmers.Wiley interdisciplinary reviews. Computational molecular scienceArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Actin waves are complex dynamical patterns of the dendritic network of filamentous actin in eukaryotes. We developed a model of actin waves in PTEN-deficient Dictyostelium discoideum by deriving an approximation of the dynamics of discrete actin filaments and combining it with a signaling pathway that controls filament branching. This signaling pathway, together with the actin network, contains a positive feedback loop that drives the actin waves. Our model predicts the structure, composition, and dynamics of waves that are consistent with existing experimental evidence, as well as the biochemical dependence on various protein partners. Simulation suggests that actin waves are initiated when local actin network activity, caused by an independent process, exceeds a certain threshold. Moreover, diffusion of proteins that form a positive feedback loop with the actin network alone is sufficient for propagation of actin waves at the observed speed of * 6 mm/min. Decay of the wave back can be caused by scarcity of network components, and the shape of actin waves is highly dependent on the filament disassembly rate. The model allows retraction of actin waves and captures formation of new wave fronts in broken waves. Our results demonstrate that a delicate balance between a positive feedback, filament disassembly, and local availability of network components is essential for the complex dynamics of actin waves.
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