SynthesisPloS one2013
Ex-PRESS implantation versus trabeculectomy in uncontrolled glaucoma: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 8 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Device-modified trabeculectomy for glaucoma.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Device-modified trabeculectomy for glaucoma.The Cochrane database of systematic reviews · 2015Pooled it
- Central corneal sensitivity after small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a meta-analysis of comparative studies.BMC ophthalmology · 2015Pooled it
- Ologen implant versus mitomycin C for trabeculectomy: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Meta-analysis of randomized controlled trials comparing EX-PRESS implantation with trabeculectomy for open-angle glaucoma.PloS one · 2014Pooled it
- Ex-PRESS implantation versus trabeculectomy in open-angle glaucoma: a meta-analysis of randomized controlled clinical trials.PloS one · 2014Pooled it
- Fornix-based versus limbus-based conjunctival flap in trabeculectomy: a quantitative evaluation of the evidence.PloS one · 2013Pooled it
- A 3-Year Post-Marketing Surveillance Study of EX-PRESS™ Glaucoma Filtration Device in Japanese Eyes.Advances in therapy · 2026Article
- Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification.Indian journal of ophthalmology · 2022Article
- Modified Trabeculectomy versus Glaucoma Drainage Implant Surgery: A Retrospective Comparative Study for Refractory Glaucoma Treatment.Oxidative medicine and cellular longevity · 2022Article
- Combined Phacoemulsification and Ex-PRESS Implant with Everting Suture in Primary Angle-Closure Glaucoma: Survival Analysis and Predictive Factors.Journal of clinical medicine · 2021Article
- Ex-PRESS shunt implantation for intractable glaucoma with posterior chamber phakic intraocular lens: a case report.BMC ophthalmology · 2021Article
- Comparison of the 1-year postoperative results of phacoemulsification-trabeculectomy and phacoemulsification-ExPRESS miniature shunt combined surgeries.International ophthalmology · 2020Article
- A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia.Journal of current ophthalmology · 2017Review
- Surgical treatment of neovascular glaucoma with Ex-PRESS glaucoma shunt: Case report.Medicine · 2017Article
- Effect of glaucoma implant surgery on intraocular pressure reduction, flare count, anterior chamber depth, and corneal endothelium in primary open-angle glaucoma.Japanese journal of ophthalmology · 2017Article
- Dry eye and corneal sensitivity after small incision lenticule extraction and femtosecond laser-assistedInternational journal of ophthalmology · 2017Article
- Ex-PRESS implantation versus trabeculectomy in Chinese patients with POAG: fellow eye pilot study.International journal of ophthalmology · 2017Article
- Ex-PRESS implantation with phacoemulsification in POAG versus CPACG.International journal of ophthalmology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy and tolerability of Ex-PRESS implantation (Ex-Press) compared with trabeculectomy (Trab) in the treatment of patients with uncontrolled glaucoma.
methodsA comprehensive literature meta-analysis was performed according to the Cochrane Collaboration methodology to identify controlled clinical trials comparing Ex-Press with Trab. Efficacy estimates were measured by weight mean difference (WMD) for the percentage intraocular pressure (IOP) reduction from baseline to end-point, odds ratio (OR) for complete success, and qualified success rates. Tolerability estimates were measured by OR for adverse events. All outcomes were reported with a 95% confidence interval (CI). Data were synthesized by Stata 11.0 SE for Windows.
resultsEight controlled clinical trials meeting the predefined criteria were included in the meta-analysis. A total of 605 eyes from 559 patients with medically uncontrolled glaucoma were included. The weighted mean difference of the percentage IOP reduction from baseline was 2.33 (95% confidence interval: -2.59-7.24) when comparing Ex-Press with Trab. Ex-Press was associated with numerically greater, but nonsignificant, IOP lowering efficacy than Trab. The pooled odds ratio comparing Ex-Press with Trab were 0.93 (0.39, 2.23) for the complete success rate and 1.00 (0.39, 2.56) for the qualified success rate. Ex-Press was associated with a significantly lower frequency of hypotony and hyphema than Trab, with pooled ORs of 0.29 (0.13, 0.65) and 0.36 (0.13, 0.97), respectively.
conclusionEx-Press was associated with equivalent efficacy to Trab in lowering IOP. Comparable proportions of patients reached the IOP target with Ex-Press and Trab. Ex-Press was better tolerated than Trab.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.