ArticleJournal of neurophysiology2013
Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly.Current biology : CB · 2026Article
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- Development and experience-dependent modulation of the defensive behaviors of mice to visual threats.The journal of physiological sciences : JPS · 2022Article
- Reconnecting Eye to Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity.Neural development · 2014Article
- Role of emergent neural activity in visual map development.Current opinion in neurobiology · 2014Review
- Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Prior to eye opening, waves of spontaneous activity sweep across the developing retina. These "retinal waves," together with genetically encoded molecular mechanisms, mediate the formation of visual maps in the brain. However, the specific role of wave activity in synapse development in retino-recipient brain regions is unclear. Here we compare the functional development of synapses and the morphological development of neurons in the superior colliculus (SC) of wild-type (WT) and transgenic (β2-TG) mice in which retinal wave propagation is spatially truncated (Xu HP, Furman M, Mineur YS, Chen H, King SL, Zenisek D, Zhou ZJ, Butts DA, Tian N, Picciotto MR, Crair MC. Neuron 70: 1115-1127, 2011). We use two recently developed brain slice preparations to examine neurons and synapses in the binocular vs. mainly monocular SC. We find that retinocollicular synaptic strength is reduced whereas the number of retinal inputs is increased in the binocular SC of β2-TG mice compared with WT mice. In contrast, in the mainly monocular SC the number of retinal inputs is normal in β2-TG mice, but, transiently, synapses are abnormally strong, possibly because of enhanced activity-dependent competition between local, "small" retinal wave domains. These findings demonstrate that retinal wave size plays an instructive role in the synaptic and morphological development of SC neurons, possibly through a competitive process among retinofugal axons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.