ArticleJournal of virology2013
A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- The V protein in oncolytic Newcastle disease virus promotes HepG2 hepatoma cell proliferation at the single-cell level.BMC cancer · 2023Article
- Identification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity.Veterinary research · 2021Article
- Residues 315 and 369 in HN Protein Contribute to the Thermostability of Newcastle Disease Virus.Frontiers in microbiology · 2020Article
- Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase.Glycoconjugate journal · 2017Article
- Contribution of HN protein length diversity to Newcastle disease virus virulence, replication and biological activities.Scientific reports · 2016Article
- Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity.Scientific reports · 2015Article
- Review
- Host Innate Immune Responses of Ducks Infected with Newcastle Disease Viruses of Different Pathogenicities.Frontiers in microbiology · 2015Article
- Newcastle disease virus: current status and our understanding.Virus research · 2014Review
- Activation of paramyxovirus membrane fusion and virus entry.Current opinion in virology · 2014Review
- Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.Journal of virology · 2014Article
- Package of NDV-pseudotyped HIV-Luc virus and its application in the neutralization assay for NDV infection.PloS one · 2014Article
- Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability.Journal of virology · 2013Article
- A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion.Journal of virology · 2013Article
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Authors and funding
2 authors.
Funding
Abstract
Newcastle disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins. Substitutions for NDV HN stalk residues A89, L90, and L94 block fusion by modulating formation of the HN-F complex. Here, we demonstrate that a nearby L97A substitution, though previously shown to block fusion, allows efficient HN-F complex formation and likely acts by preventing changes in the HN stalk required for triggering of the bound F protein.
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Registered trials
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