SynthesisJournal of clinical microbiology2013
PCR-based diagnosis of prosthetic joint infection.
Synthesis in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 7 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Diagnostic and prognostic relevance of plain radiographs for periprosthetic joint infections of the hip: a literature review.European journal of medical research · 2024Pooled it
- Meta-analysis in periprosthetic joint infection: a global bibliometric analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection.Scientific reports · 2017Pooled it
- The application of sonication in diagnosis of periprosthetic joint infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Pooled it
- Accuracy of diagnostic tests for prosthetic joint infection: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Meta-analysis of sonication fluid samples from prosthetic components for diagnosis of infection after total joint arthroplasty.Journal of clinical microbiology · 2014Pooled it
- Evaluation of white cell count and differential in synovial fluid for diagnosing infections after total hip or knee arthroplasty.PloS one · 2014Pooled it
- Occult Infection in Aseptic Joint Loosening and the Diagnostic Role of Implant Sonication.BioMed research international · 2015Trial
- Performance and potential utility of the BioFire Joint Infection Panel with synovial fluid and joint tissue specimens.Journal of clinical microbiology · 2025Article
- Beyond Cultures: The Evolving Role of Molecular Diagnostics, Synovial Biomarkers and Artificial Intelligence in the Diagnosis of Prosthetic Joint Infections.Journal of clinical medicine · 2025Review
- The Ongoing Struggle to Find a Gold Standard for PJI Diagnosis.Reports (MDPI) · 2025Review
- Review
- Can pre-analytical procedures improve microbiological culture yield in patients with periprosthetic infections?BMC microbiology · 2024Article
- Universal PCR for bacteria, mycobacteria, and fungi: a 10-year retrospective review of clinical indications and patient outcomes.Journal of clinical microbiology · 2023Article
- Periprosthetic Joint Infection Diagnosis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Diagnostic Role of mNGS in Polymicrobial Periprosthetic Joint Infection.Journal of clinical medicine · 2023Article
- Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections.Microorganisms · 2022Review
- Sonication of explants enhances the diagnostic accuracy of synovial fluid and tissue cultures and can help determine the appropriate antibiotic therapy for prosthetic joint infections.International orthopaedics · 2022Article
- Tissue-level cytokines in a rodent model of chronic implant-associated infection.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Clinical characteristics and risk factors for culture-negative periprosthetic joint infections.Journal of orthopaedic surgery and research · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a meta-analysis to evaluate use of PCR assays for diagnosis of prosthetic joint infection (PJI). The pooled sensitivity and specificity were 0.86 (95% confidence interval [CI], 0.77 to 0.92) and 0.91 (CI, 0.81 to 0.96), respectively. Subgroup analyses showed that use of tissue samples may improve sensitivity, and quantitative PCR and sonication of prostheses fluid may improve specificity. The results showed that PCR is reliable and accurate for detection of PJI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.