Evidence map›Paper›PMID 23740373›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2013

Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure.

Teresa Pellegrino, Mario Petretta, Serena De Luca, Stefania Paolillo, Antonio Boemio, Raffaella Carotenuto, Maria Piera Petretta, Carmine di Nuzzo, Pasquale Perrone-Filardi, Alberto Cuocolo

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Article in European journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. CardiacPharmaceuticals (Basel, Switzerland) · 2022
    Review
  3. Relationship between heart rate response and cardiac innervation in patients with suspected or known coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  4. Quality and utility of [Annals of nuclear medicine · 2021
    Article
  5. Focal reduction in left ventricularJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  6. Impact of body mass index on cardiac adrenergic derangement in heart failure patients: aEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
  7. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  8. Article
  9. Influence of ROI definition on the heart-to-mediastinum ratio in planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  10. Article
  11. MyocardialJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  12. Cardiac sympathetic activity in chronic heart failure: cardiacNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016
    Review
  13. Impact of aging on cardiac sympathetic innervation measured byEuropean journal of nuclear medicine and molecular imaging · 2016
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The "gray zone" for the heart to mediastinum MIBG uptake ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
  20. Quantification of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratios: not so simple after all.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teresa PellegrinoInstitute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
Mario Petretta
Serena De Luca
Stefania Paolillo
Antonio Boemio
Raffaella Carotenuto
Maria Piera Petretta
Carmine di Nuzzo
Pasquale Perrone-Filardi
Alberto Cuocolo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImaging of the cardiac autonomic system with (123)I-metaiodobenzylguanidine (MIBG) is useful in the evaluation of patients with a variety of cardiac conditions, including heart failure (HF), but few data are available about the reproducibility of this technique. We assessed the observer reproducibility of the results from a low-dose (123)I-MIBG cardiac imaging protocol in patients with HF.

methodsA total of 74 patients (62 men, age 67 ± 10 years) with HF and left ventricular systolic dysfunction (ejection fraction 31 ± 7 %) underwent low-dose (111 MBq) planar and single-photon emission computed tomography (SPECT) (123)I-MIBG cardiac sympathetic imaging. The intraclass coefficient of correlation (ICC), Lin's concordance correlation coefficient, and Bland-Altman analysis were used to evaluate the intraobserver and interobserver reproducibility of early and late heart-to-mediastinum (H/M) ratios and of defect scores on SPECT images. The κ statistic was used to evaluate the concordance rates for the identification of patients with a low H/M ratio (<1.60) on late planar imaging.

resultsThe differences between measurements obtained twice by the same examiner and by two examiners were negligible for both early and late H/M ratios and for SPECT defect scores. These findings were confirmed by the results of Bland-Altman analysis, and ICC and Lin's coefficient values were excellent (>0.90) for all measurements. For the identification of patients with a low H/M ratio, the κ values were 0.90 for intraobserver concordance and 0.83 for interobserver concordance.

conclusionThe present study showed a high observer reproducibility of planar H/M ratios and SPECT defect scores using a low-dose (123)I-MIBG cardiac imaging protocol in patients with HF.

Indexed as

3-IodobenzylguanidineRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonAgedFemaleHeart FailureHumansMaleMiddle AgedObserver VariationReproducibility of Results3-IodobenzylguanidineRadiopharmaceuticals

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.