ArticleIntensive care medicine2013
Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study.
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Brain development in newborns and infants after ECMO.World journal of pediatrics : WJP · 2024Pooled it
- Long-term follow-up of neuropsychological complications in neonates undergoing extracorporeal membrane oxygenation: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- A systematic review of the impact of intensive care admissions on post discharge cognition in children.European journal of pediatrics · 2021Pooled it
- Neurologic Outcomes After Extracorporeal Membrane Oxygenation: A Systematic Review.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Pooled it
- Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial.Critical care (London, England) · 2022Trial
- Sedation Management in Children Supported on Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.Critical care medicine · 2017Trial
- Follow-up of neonates who received ECMO: how are they doing?European journal of pediatrics · 2026Review
- Application of extracorporeal membrane oxygenation in respiratory and circulatory support of preterm infants: a multicenter retrospective study in China.Frontiers in cardiovascular medicine · 2026Article
- Exploratory deep-learning-driven early risk stratification of significant neurological injury in pediatric extracorporeal membrane oxygenation.Frontiers in digital health · 2026Article
- Article
- How low should we go? Outcomes of ECMO in neonates with low gestational age or birth weight.Pediatric surgery international · 2025Article
- Using cerebral regional oxygen saturation and amplitude-integrated electroencephalography in neonates on extracorporeal membrane oxygenation: preliminary experience from a single center.BMC pediatrics · 2024Article
- Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension.Clinics in perinatology · 2024Review
- Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial.European journal of pediatrics · 2024Article
- Long-term follow-up in pediatric intensive care-a narrative review.Frontiers in pediatrics · 2024Review
- Long-term follow-up of patients with congenital diaphragmatic hernia.World journal of pediatric surgery · 2024Review
- Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time.Clinical epigenetics · 2023Article
- Parent-Reported Perceived Cognitive Functioning Identifies Cognitive Problems in Children Who Survived Neonatal Critical Illness.Children (Basel, Switzerland) · 2022Article
- Neonatal Pain, Opioid, and Anesthetic Exposure; What Remains in the Human Brain After the Wheels of Time?Frontiers in pediatrics · 2022Article
- Neonatal respiratory and cardiac ECMO in Europe.European journal of pediatrics · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeReporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO).
methodsIn a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (Bourdon-Vos test), eye-hand coordination (Developmental Test of Visual-Motor Integration) and behavior (Child Behavior Checklist and Teacher Report Form).
resultsIntelligence fell within normal range (mean IQ 99.9, SD 17.7, n = 125) with 91 % of the children following regular education. Significantly more children attended special education (9 %) or received extra support in regular education (39 %) compared with normative data. Slower working speed (χ(2) = 132.36, p < 0.001) and less accuracy (χ(2) = 12.90, p < 0.001) were found on the Bourdon-Vos test (n = 123) compared with normative data. Eye-hand coordination fell within the normal range (mean 97.6, SD 14.3, n = 126); children with congenital diaphragmatic hernia scored lowest but still normally (mean 91.0, SD 16.4, n = 28). Mothers (n = 117) indicated more somatic and attention behavior problems; teachers (n = 115) indicated more somatic, social, thought, aggression and total problems compared with normative data. Mothers indicated more somatic problems than teachers (p = 0.003); teachers reported more attention problems than mothers (p = 0.036; n = 111).
conclusionsEight-year-old children treated with neonatal ECMO fall in the normal range of intelligence with problems with concentration and behavior. Long-term follow-up for children treated with neonatal ECMO should focus on early detection of (subtle) learning deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.