Observational studyClinical research in cardiology : official journal of the German Cardiac Society2013
Severity of cardiac impairment in the early stage of community-acquired sepsis determines worse prognosis.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- [Indocyanine green elimination for the evaluation of liver function: prognostic value in patients with community-acquired sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Trial
- [Septic cardiomyopathy-diagnosis and estimation of disease severity].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Sepsis-induced cardiomyopathy: understanding pathophysiology and clinical implications.Archives of toxicology · 2025Review
- Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance.Journal of intensive medicine · 2024Article
- A novel speckle-tracking echocardiography parameter assessing left ventricular afterload.European journal of clinical investigation · 2024Article
- Levosimendan in the Treatment of Patients with Severe Septic Cardiomyopathy.Life (Basel, Switzerland) · 2023Article
- Afterload-related cardiac performance is a powerful hemodynamic predictor of mortality in patients with chronic heart failure.Therapeutic advances in chronic disease · 2023Article
- Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review.Emergency medicine international · 2023Review
- ANXA1sp Protects against Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death via SIRT3-Mediated p53 Deacetylation.Mediators of inflammation · 2023Article
- Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis.Annals of intensive care · 2022Article
- Dissecting the correlates of N-terminal prohormone brain natriuretic peptide in acute infective endocarditis.Infection · 2022Article
- Utility of Cardiac Power Hemodynamic Measurements in the Evaluation and Risk Stratification of Cardiovascular Conditions.Healthcare (Basel, Switzerland) · 2022Review
- Review
- Septic cardiomyopathy: Diagnosis and management.Journal of intensive medicine · 2022Review
- The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit.Heart and vessels · 2021Article
- Afterload-related cardiac performance predicts prognosis in critical ill patients with sepsis: A prospective observational pilot study.Medicine · 2021Observational
- Development and internal validation of a simple prognostic score for early sepsis risk stratification in the emergency department.BMJ open · 2021Article
- Pathophysiology of sepsis-induced cardiomyopathy.Nature reviews. Cardiology · 2021Review
- Afterload-related cardiac performance identifies cardiac impairment and associates with outcome in patients with septic shock: a retrospective cohort study.Journal of intensive care · 2021Article
- Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Review
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn sepsis, the reduced systemic vascular resistance (SVR) can lead to a compensatory increase in cardiac output (CO). This may mimic a normal cardiac function although there is already a sepsis-induced myocardial depression. On a cohort of patients with septic multi-organ dysfunction syndrome, we have recently developed a method to correlate the actual CO to the afterload (estimated by SVR) and introduced the parameter "afterload-related cardiac performance" (ACP), which indicates if the rise of CO is adequate for the particular SVR. In this present study it was to be investigated, if ACP can reveal septic cardiomyopathy in patients with community-acquired sepsis in the early state soon after admission to the emergency department (ED), and if there is a prognostic relevance of septic cardiomyopathy defined by ACP. Results were compared to cardiac index (CI) and cardiac power index (CPI).
methodsAdults presenting at the ED with sepsis were included. ACP, CI and CPI were calculated at the time of admission, after 24, and 72 h. They were correlated to severity of disease and the prognostic values were analyzed.
resultsA total of 141 patients were included. Only ACP was significantly influenced by severity of sepsis, whereas CI and CPI were not. ACP was the only hemodynamic parameter predicting mortality: nonsurvivors had lower ACP values at the time of admission to the ED (66.9 vs. 88.9 %, p < 0.05) and ACP predicted non-survival with an AUC value of 0.72, p = 0.003. Cardiac impairment defined by an ACP value of 80 % or below determined worse prognosis.
conclusionsSeptic cardiomyopathy occurs already at the early stage of disease and is of prognostic relevance. It might be recognized best, if cardiac function is correlated to afterload.
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