ArticleJournal of molecular evolution2013
Computational identification and evolutionary relationships of the microRNA gene cluster miR-71/2 in protostomes.
Article in Journal of molecular evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- Article
- Elucidation of the MicroRNA Transcriptome in Western Corn Rootworm Reveals Its Dynamic and Evolutionary Complexity.Genomics, proteomics & bioinformatics · 2021Article
- Computational prediction and characterisation of miRNAs and their pathway genes in human schistosomiasis caused by Schistosoma haematobium.Memorias do Instituto Oswaldo Cruz · 2020Article
- Deep sequencing of small RNAs reveals the repertoire of miRNAs and piRNAs in Biomphalaria glabrata.Memorias do Instituto Oswaldo Cruz · 2020Article
- Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarianGenomics data · 2017Article
- Computational identification and characterization of miRNAs and their target genes from five cyprinidae fishes.Saudi journal of biological sciences · 2017Article
- Computational prediction of candidate miRNAs and their potential functions in biomineralization in pearl oyster Pinctada martensii.Saudi journal of biological sciences · 2016Article
- Identification of microRNA genes in three opisthorchiids.PLoS neglected tropical diseases · 2015Article
- Identification of differentially expressed microRNAs in Culex pipiens and their potential roles in pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Sex-biased expression of microRNAs in Schistosoma mansoni.PLoS neglected tropical diseases · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into ~20-24 nt molecules that can regulate the gene expression post-transcriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia.
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