ArticlePediatric nephrology (Berlin, Germany)2013
Left ventricular diastolic dysfunction by tissue Doppler echocardiography in pediatric chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Neuron-specific enolase and brain-derived neurotrophic factor as developmental neurovascular markers in chronic kidney disease and kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Article
- Diastolic echocardiographic parameters identify pediatric kidney transplant recipients with structural myocardial alterations.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypertension control and its association with left ventricular hypertrophy in children and young people on dialysis: a longitudinal study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Left ventricular myocardial functions in pediatric patients with primary nephrotic syndrome: a comprehensive evaluation using conventional echocardiography, two-dimensional speckle tracking, and three-dimensional echocardiography.Italian journal of pediatrics · 2025Observational
- Association between extracellular DNA levels, markers of inflammation and left ventricular mass index in children with chronic kidney disease.Scientific reports · 2025Observational
- Changes in Cardiac Structure and Function of Recipients after Kidney Transplantation.Journal of clinical medicine · 2024Article
- Echocardiogram screening in pediatric dialysis and transplantation.Pediatric nephrology (Berlin, Germany) · 2023Review
- Left Ventricular Diastolic Dysfunction Among Youth with Obesity and History of Elevated Blood Pressure.The Journal of pediatrics · 2021Article
- The Impact of Bone Mineral Biomarkers on Cardiac Dysfunction in Predialysis Chronic Kidney Disease Children.International journal of pediatrics · 2021Article
- Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study.BMC nephrology · 2020Observational
- Left ventricular stiffness in paediatric patients with end-stage kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Improved blood pressure and left ventricular remodelling in children on chronic intermittent haemodialysis: a longitudinal study.Pediatric nephrology (Berlin, Germany) · 2019Article
- Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study.Scientific reports · 2019Observational
- Comparison of echocardiographic changes in children with primary hypertension and hypertension due to mild to moderate chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Cardiovascular risk in children and adolescents with end stage renal disease.Clinics (Sao Paulo, Brazil) · 2019Article
- The FGF23-Klotho axis and cardiac tissue Doppler imaging in pediatric chronic kidney disease-a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2018Observational
- Longitudinal assessment of myocardial function in childhood chronic kidney disease, during dialysis, and following kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2017Article
- Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease.Pediatric radiology · 2017Article
- Assessing longitudinal trends in cardiac function among pediatric patients with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Left ventricular mass and systolic function in children with chronic kidney disease-comparing echocardiography with cardiac magnetic resonance imaging.Pediatric nephrology (Berlin, Germany) · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundMyocardial dysfunction is common in chronic kidney disease (CKD) and related to poor outcomes. New non-invasive methods to assess cardiac function have been introduced, but comparative studies evaluating their clinical usefulness in pediatric CKD are lacking. We studied left ventricular (LV) function in pediatric CKD and renal transplant patients, comparing conventional pulse-wave Doppler echocardiography (cPWD) with newer tissue Doppler imaging (TDI) and relating the results to known cardiovascular risk factors.
methodsThe study included 34 children/adolescents with CKD stages 2-5, 44 renal transplant patients and 19 patients with a normal renal function. The mean age was 11.4 (range 0.8-18.8) years.
resultsBoth patient groups had significantly lower LV diastolic function than those with a normal renal function. The most sensitive determinants were TDI E'/A' and cPWD E/TDI E' ratios. In a stepwise linear regression analysis, high blood pressure, young age and the presence of albuminuria all independently predicted LV diastolic function.
conclusionsOur study confirms the high prevalence of LV diastolic dysfunction in pediatric CKD patients and following renal transplantation, where TDI appears to be more sensitive than cPWD in assessing early myocardial dysfunction. Our results also underline the importance of preventive measures, such as rigorous blood pressure control, in pediatric CKD.
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