ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Amygdala lesions reduce cataplexy in orexin knock-out mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 106 citations in OpenAlex.
- Oxytocin promotes socially triggered cataplexy.Nature neuroscience · 2026Article
- Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system.PLoS biology · 2026Article
- The G protein-coupled estrogen receptor in the nucleus accumbens mediates the estrogen-induced increase in cataplexy-like behavior.Scientific reports · 2026Article
- Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025Review
- The role of orexin and MCH neurons in the hypothalamus in sleep-wake regulation and learning-forgetting balance.Frontiers in neuroscience · 2025Review
- The Role and Mechanisms of the Hypocretin System in Zebrafish (International journal of molecular sciences · 2024Review
- Activation of the nucleus accumbens promotes place preference and counteracts stress-induced hyperthermia.iScience · 2024Article
- Neural Control of REM Sleep and Motor Atonia: Current Perspectives.Current neurology and neuroscience reports · 2023Review
- Prefrontal Cortical Regulation of REM Sleep.Research square · 2023Article
- Prefrontal cortical regulation of REM sleep.Nature neuroscience · 2023Article
- Article
- Activation of the rostral nucleus accumbens shell by optogenetics induces cataplexy-like behavior in orexin neuron-ablated mice.Scientific reports · 2023Article
- Amygdala neurocircuitry at the interface between emotional regulation and narcolepsy with cataplexy.Frontiers in neuroscience · 2023Review
- Brain glucose metabolism and nigrostriatal degeneration in isolated rapid eye movement sleep behaviour disorder.Brain communications · 2023Article
- Narcolepsy-like symptoms triggered by lemborexant in the context of hyperactive delirium in a patient with bipolar depression: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
- Activity of putative orexin neurons during cataplexy.Molecular brain · 2022Article
- Histamine as an Alert Signal in the Brain.Current topics in behavioral neurosciences · 2022Review
- Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice.Communications biology · 2021Article
- The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Narcolepsy is characterized by excessive sleepiness and cataplexy, sudden episodes of muscle weakness during waking that are thought to be an intrusion of rapid eye movement sleep muscle atonia into wakefulness. One of the most striking aspects of cataplexy is that it is often triggered by strong, generally positive emotions, but little is known about the neural pathways through which positive emotions trigger muscle atonia. We hypothesized that the amygdala is functionally important for cataplexy because the amygdala has a role in processing emotional stimuli and it contains neurons that are active during cataplexy. Using anterograde and retrograde tracing in mice, we found that GABAergic neurons in the central nucleus of the amygdala heavily innervate neurons that maintain waking muscle tone such as those in the ventrolateral periaqueductal gray, lateral pontine tegmentum, locus ceruleus, and dorsal raphe. We then found that bilateral, excitotoxic lesions of the amygdala markedly reduced cataplexy in orexin knock-out mice, a model of narcolepsy. These lesions did not alter basic sleep-wake behavior but substantially reduced the triggering of cataplexy. Lesions also reduced the cataplexy events triggered by conditions associated with high arousal and positive emotions (i.e., wheel running and chocolate). These observations demonstrate that the amygdala is a functionally important part of the circuitry underlying cataplexy and suggest that increased amygdala activity in response to emotional stimuli could directly trigger cataplexy by inhibiting brainstem regions that suppress muscle atonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.