ArticleCellular and molecular life sciences : CMLS2013
Paleoproteomic study of the Iceman's brain tissue.
Article in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- [Mummy research-Clinical consequences of Ötzi's arrow injury : German Congress for Orthopedics and Trauma Surgery (DKOU) science slam 2025].Unfallchirurgie (Heidelberg, Germany) · 2026Article
- New insights on Ötzi's injuries from a clinical perspective.Scientific reports · 2025Article
- Article
- Human brains preserve in diverse environments for at least 12 000 years.Proceedings. Biological sciences · 2024Article
- Curated cauldrons: Preserved proteins from early copper-alloy vessels illuminate feasting practices in the Caucasian steppe.iScience · 2023Article
- Paleoproteomics.Chemical reviews · 2022Review
- [The Iceman : Life scenarios and pathological findings from 30 years of research on the glacier mummy "Ötzi"].Der Pathologe · 2021Review
- Ancient protein analysis in archaeology.Science advances · 2021Review
- Review
- The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals.Current biology : CB · 2018Article
- Paleoproteomics of the Dental Pulp: The plague paradigm.PloS one · 2017Article
- Identification of proteins from 4200-year-old skin and muscle tissue biopsies from ancient Egyptian mummies of the first intermediate period shows evidence of acute inflammation and severe immune response.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase.Oncotarget · 2016Article
- Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior.Scientific reports · 2014Article
- Decoding the iceman's death?Cellular and molecular life sciences : CMLS · 2014Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Tyrolean Iceman, a Copper-age ice mummy, is one of the best-studied human individuals. While the genome of the Iceman has largely been decoded, tissue-specific proteomes have not yet been investigated. We studied the proteome of two distinct brain samples using gel-based and liquid chromatography-mass spectrometry-based proteomics technologies together with a multiple-databases and -search algorithms-driven data-analysis approach. Thereby, we identified a total of 502 different proteins. Of these, 41 proteins are known to be highly abundant in brain tissue and 9 are even specifically expressed in the brain. Furthermore, we found 10 proteins related to blood and coagulation. An enrichment analysis revealed a significant accumulation of proteins related to stress response and wound healing. Together with atomic force microscope scans, indicating clustered blood cells, our data reopens former discussions about a possible injury of the Iceman's head near the site where the tissue samples have been extracted.
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