Evidence map›Paper›PMID 23739801›Full record

ReviewInternational journal of oncology2013

Immunostimulatory properties and antitumor activities of glucans (Review).

Luca Vannucci, Jiri Krizan, Petr Sima, Dmitry Stakheev, Fabian Caja, Lenka Rajsiglova, Vratislav Horak, Mustafa Saieh

Open access · hybridAbstract readReview
In one paragraph

Review in International journal of oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.

  1. Effects ofInternational journal of molecular sciences · 2018
    Pooled it
  2. Trial
  3. Review
  4. Glycoconjugate Vaccines Against Nosocomial Klebsiella pneumoniae Infections.Advances in experimental medicine and biology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Glucans: A Therapeutic Alternative for Sepsis Treatment.Journal of immunology research · 2024
    Review
  14. Review
  15. Potent induction of trained immunity byFrontiers in immunology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Luca VannucciLaboratory of Immunotherapy, Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of Czech Republic, v.v.i., 142 20 Prague 4, Czech Republic. vannucci@biomed.cas.cz
Jiri Krizan
Petr Sima
Dmitry Stakheev
Fabian Caja
Lenka Rajsiglova
Vratislav Horak
Mustafa Saieh
Czech Academy of Sciences · CZCzech Academy of Sciences, Institute of Microbiology · CZCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZUniversity of Al Jabal Al Gharbi · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New foods and natural biological modulators have recently become of scientific interest in the investigation of the value of traditional medical therapeutics. Glucans have an important part in this renewed interest. These fungal wall components are claimed to be useful for various medical purposes and they are obtained from medicinal mushrooms commonly used in traditional Oriental medicine. The immunotherapeutic properties of fungi extracts have been reported, including the enhancement of anticancer immunity responses. These properties are principally related to the stimulation of cells of the innate immune system. The discovery of specific receptors for glucans on dendritic cells (dectin-1), as well as interactions with other receptors, mainly expressed by innate immune cells (e.g., Toll-like receptors, complement receptor-3), have raised new attention toward these products as suitable therapeutic agents. We briefly review the characteristics of the glucans from mycelial walls as modulators of the immunity and their possible use as antitumor treatments.

Indexed as

Adjuvants, ImmunologicAgaricalesAnimalsAntineoplastic Agentsbeta-GlucansCell ExtractsDectin-1Dendritic CellsHumansImmunity, InnateLectins, C-TypeMacrophagesMedicine, East Asian TraditionalMiceSignal TransductionAdjuvants, ImmunologicAntineoplastic Agentsbeta-GlucansCell ExtractsDectin-1Lectins, C-Type

Identifiers

PMID23739801
PMCPMC3775562
OpenAlexW2085095860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.