ArticleInternational journal of molecular medicine2013
Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells.
Article in International journal of molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 98 citations in OpenAlex.
- Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.Biotech (Basel (Switzerland)) · 2026Review
- Structures, characteristics, and anticancer mechanisms of taxanes, beta-glucans, and isothiocyanates.Molecular biology reports · 2026Review
- High-Value Brown Algae Extracts Using Deep Eutectic Solvents and Microwave-Assisted Extraction.Foods (Basel, Switzerland) · 2025Article
- Seaweed in the Diet as a Source of Bioactive Metabolites and a Potential Natural Immunity Booster: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- In vitro anticancer potential of laminarin and fucoidan from Brown seaweeds.Scientific reports · 2023Article
- Transcriptome and proteome analysis reveals the anti-cancer properties of Hypnea musciformis marine macroalga extract in liver and intestinal cancer cells.Human genomics · 2023Article
- Emerging Role of Plant-Based Dietary Components in Post-Translational Modifications Associated with Colorectal Cancer.Life (Basel, Switzerland) · 2023Review
- Potential therapeutic target for polysaccharide inhibition of colon cancer progression.Frontiers in medicine · 2023Review
- Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases.Marine drugs · 2022Review
- Laminarin Attenuates ROS-Mediated Cell Migration and Invasiveness through Mitochondrial Dysfunction in Pancreatic Cancer Cells.Antioxidants (Basel, Switzerland) · 2022Article
- Modular and mechanistic changes across stages of colorectal cancer.BMC cancer · 2022Article
- Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases.Frontiers in nutrition · 2022Review
- Isolation, identification, and biochemical characterization of a novel bifunctional phosphomannomutase/phosphoglucomutase from the metagenome of the brown algaFrontiers in microbiology · 2022Article
- Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications.International journal of molecular sciences · 2021Review
- Laminarin, a Major Polysaccharide in Stramenopiles.Marine drugs · 2021Review
- Integrated Network Pharmacology Analysis andMolecules (Basel, Switzerland) · 2021Article
- Identification ofAnnals of translational medicine · 2021Article
- Screening and verification of hub genes involved in osteoarthritis using bioinformatics.Experimental and therapeutic medicine · 2021Article
- Article
- Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laminarin, found in marine brown algae, is used as a carbohydrate reserve for phytoplankton; however, it is also used in traditional Chinese medicine, and has been shown to have several biological activities, including anticancer activities. In this study, we examined the mechanisms through which laminarin from Laminaria digitata induces apoptosis in HT-29 colon cancer cells, as well as the involvement of the ErbB signaling pathway. Cell viability assay revealed that laminarin induced cell death in a dose-dependent manner. Cell cycle analysis revealed that laminarin increased the percentage of cells in the sub-G1 and G2-M phase. Western blot analysis demonstrated that laminarin inhibited the heregulin-stimulated phosphorylation of ErbB2. A decrease in cellular proliferation was also observed; this was found to be dependent on ErbB, which activates c-Jun N-terminal kinase. These findings demonstrate the important role of the epidermal growth factor receptor in colon cancer tumorigenesis, and suggest the potential of laminarin as a bio-functional food with anticancer effects on human colon cancer.
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