Evidence map›Paper›PMID 23739109›Full record

ReviewContinuum (Minneapolis, Minn.)2013

Dietary treatment of intractable epilepsy.

Mackenzie C Cervenka, Eric H Kossoff

3 registry-linked trialsOpen access · greenAbstract readCase ReportsReview
In one paragraph

Review in Continuum (Minneapolis, Minn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02497105 nacompletednot on this mapstarted 2015, after this paper: background citation

Ketogenic Diet Program for Epilepsy

TypeinterventionalSponsorShriners Hospitals for ChildrenRan2015 to 2018Enrolled30ConditionsEpilepsyArmsKetogenic Diet
NCT04542629 phase4unknown statusnot on this mapstarted 2020, after this paper: background citation

Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children Attending Assiut Pediatric University Hospital

TypeinterventionalSponsorAssiut UniversityRan2020 to 2022Enrolled140ConditionsRefractory EpilepsyArmsRiTUXimab Injection [Rituxan]
NCT05219006 nacompletednot on this mapstarted 2021, after this paper: background citation

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2023Enrolled17ConditionsNon Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder, Ketogenic DietingArmsketogenic dieting, healthy dieting
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
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  4. Review
  5. Article
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  10. When Drugs Do Not Work: Alternatives to Antiseizure Medications.Current neurology and neuroscience reports · 2020
    Review
  11. Review
  12. Lessons learned from recent clinical trials of ketogenic diet therapies in adults.Current opinion in clinical nutrition and metabolic care · 2019
    Review
  13. Article
  14. Review
  15. Review
  16. Ketogenic Diets for Adult Neurological Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mackenzie C CervenkaDepartment of Neurology, Epilepsy Center, Johns Hopkins University School of Medicine, 600 North Wolfe St, Meyer 2-147, Baltimore, MD 21287, USA. mcerven1@jhmi.edu
Eric H Kossoff
Johns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewDietary therapies for seizure management date back further than pharmacologic interventions, but many neurologists are not familiar with these treatment options. This introduction to dietary therapies will discuss administration of ketogenic diets, comparisons between diet types, evidence-based efficacy of diet therapies in epilepsy treatment, and management of side effects. This review will provide the general neurologist with the skills to identify appropriate candidates for these treatments and to offer comprehensive ongoing care. RECENT

findingsIn adults and children with medically resistant epilepsy, studies have consistently shown a greater than 50% reduction in seizure frequency in approximately one-half of patients within days to months after starting dietary therapy. SUMMARY: Dietary treatment options for epilepsy include the classic ketogenic diet, the medium-chain triglyceride diet, the modified Atkins diet, and the low glycemic index treatment. These were first used to control seizures in children with intractable epilepsy, but in recent years have also been demonstrated to be safe and effective in children and adults with a broad range of seizure types and are being used with increased frequency worldwide.

Indexed as

AdultChildClinical Trials as TopicEpilepsyFemaleHumansMale

Identifiers

PMID23739109
PMCPMC10563885
OpenAlexW2023892402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.