Trial reportBMJ (Clinical research ed.)2013
Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care.
Trial report in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000367 (Prevention of Suicide in the Elderly), which is not on this map. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Suicide in the Elderly
Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Pooled it
- Collaborative Care for Psychiatric Disorders in Older Adults: A Systematic Review.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies.BMJ (Clinical research ed.) · 2017Pooled it
- A systematic review of physical illness, functional disability, and suicidal behaviour among older adults.Aging & mental health · 2016Pooled it
- The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review.Journal of psychosomatic research · 2015Pooled it
- Frailty and Depression in Late Life: A High-Risk Comorbidity With Distinctive Clinical Presentation and Poor Antidepressant Response.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- "Do More, Feel Better": Pilot RCT of Lay-Delivered Behavioral Activation for Depressed Senior Center Clients.Behavior therapy · 2022Trial
- Assessing rates and contextual predictors of 5-year mortality among HIV-infected and HIV-uninfected individuals following HIV testing in Durban, South Africa.BMC infectious diseases · 2019Trial
- Specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression.International journal of geriatric psychiatry · 2018Trial
- The role of late life depressive symptoms on the trajectories of insomnia symptoms during antidepressant treatment.Journal of psychiatric research · 2018Trial
- Medical comorbidity in complicated grief: Results from the HEAL collaborative trial.Journal of psychiatric research · 2018Trial
- Integrating Depression Care Management into Medicare Home Health Reduces Risk of 30- and 60-Day Hospitalization: The Depression Care for Patients at Home Cluster-Randomized Trial.Journal of the American Geriatrics Society · 2016Trial
- Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial.JAMA psychiatry · 2016Trial
- Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk.Journal of general internal medicine · 2016Trial
- Does a Depression Management Program Decrease Mortality in Older Adults with Specific Medical Conditions in Primary Care? An Exploratory Analysis.Journal of the American Geriatrics Society · 2016Trial
- Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.Lancet (London, England) · 2015Trial
- Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia.Journal of Alzheimer's disease : JAD · 2015Trial
- Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial.JAMA psychiatry · 2015Trial
- Risk factors associated with depressive symptoms among institutionalized elderly in Lebanon.Scientific reports · 2026Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether an intervention to improve treatment of depression in older adults in primary care modified the increased risk of death associated with depression.
designLong term follow-up of multi-site practice randomized controlled trial (PROSPECT-Prevention of Suicide in Primary Care Elderly: Collaborative Trial).
setting20 primary care practices in New York City, Philadelphia, and Pittsburgh, USA, randomized to intervention or usual care.
participants1226 participants identified between May 1999 and August 2001 through a two stage, age stratified (60-74; ≥ 75 years) depression screening of randomly sampled patients; enrollment included patients who screened positive and a random sample of patients who screened negative.
interventionFor two years, a depression care manager worked with primary care physicians in intervention practices to provide algorithm based care for depression, offering psychotherapy, increasing antidepressant dose if indicated, and monitoring symptoms, adverse effects of drugs, and adherence to treatment. This paper reports the long term follow-up.
main outcome measureMortality risk based on a median follow-up of 98 (range 0.8-116.4) months through 2008.
resultsIn baseline clinical interviews, 396 people were classified as having major depression, 203 had clinically significant minor depression, and 627 did not meet criteria for depression. At follow-up, 405 patients had died. Patients with major depression in usual care were more likely to die than were those without depression (hazard ratio 1.90, 95% confidence interval 1.57 to 2.31). In contrast, patients with major depression in intervention practices were at no greater risk than were people without depression (hazard ratio 1.09, 0.83 to 1.44). Patients with major depression in intervention practices, relative to usual care, were 24% less likely to have died (hazard ratio 0.76, 0.57 to 1.00; P=0.05). Preliminary data on cause of death are provided. No significant effect on mortality was found for minor depression.
conclusionsOlder adults with major depression in practices provided with additional resources to intensively manage depression had a mortality risk lower than that observed in usual care and similar to older adults without depression.
trial registrationClinical trials NCT00000367.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.