ArticleMolecular plant pathology2013
Transcriptomic characterization of two major Fusarium resistance quantitative trait loci (QTLs), Fhb1 and Qfhs.ifa-5A, identifies novel candidate genes.
Article in Molecular plant pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 128 citations in OpenAlex.
- Culmorin inhibits detoxification of the mycotoxin deoxynivalenol by plant UDP-glucosyltransferases.Journal of experimental botany · 2026Article
- Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat.The Journal of biological chemistry · 2025Article
- A Comprehensive Review: Current Strategies for Detoxification of Deoxynivalenol in Feedstuffs for Pigs.Animals : an open access journal from MDPI · 2025Review
- Temporal Wheat Proteome Remodeling by Deoxynivalenol Reveals Novel Detoxification Signatures and Strategies Across Cultivars.Molecular & cellular proteomics : MCP · 2025Article
- UDP-glycosyltransferases alleviate the toxic effects of deoxynivalenol on the growth performance and gut damage of Kunming mice.Scientific reports · 2025Article
- Characterization of deoxynivalenol dehydrogenase from Pelagibacterium sp. SCN 63-126 and its application.Archives of microbiology · 2024Article
- Molecular Investigations to Improve Fusarium Head Blight Resistance in Wheat: An Update Focusing on Multi-Omics Approaches.Plants (Basel, Switzerland) · 2024Review
- Genome-wide investigation of UDP-Glycosyltransferase family in Tartary buckwheat (Fagopyrum tataricum).BMC plant biology · 2024Article
- Genetic mapping of deoxynivalenol and fusarium damaged kernel resistance in an adapted durum wheat population.BMC plant biology · 2024Article
- Similarities in Structure and Function of UDP-Glycosyltransferase Homologs from Human and Plants.International journal of molecular sciences · 2024Review
- Discovering New Substrates of a UDP-Glycosyltransferase with a High-Throughput Method.International journal of molecular sciences · 2024Article
- A diallel study to detect genetic background variation for FHB resistance in winter wheat.Scientific reports · 2024Article
- Identification and Expressional Analysis of siRNAs Responsive toInternational journal of molecular sciences · 2023Article
- Transcriptome Dynamic Analysis Reveals New Candidate Genes Associated with Resistance to Fusarium Head Blight in Two Chinese Contrasting Wheat Genotypes.International journal of molecular sciences · 2023Article
- Identification of a UDP-glucosyltransferase conferring deoxynivalenol resistance in Aegilops tauschii and wheat.Plant biotechnology journal · 2023Article
- Factors and co-factors influencing clinical manifestations in nsLTPs allergy: between the good and the bad.Frontiers in allergy · 2023Review
- Review
- The effect of the Rht1 haplotype on Fusarium head blight resistance in relation to type and level of background resistance and in combination with Fhb1 and Qfhs.ifa-5A.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Linking Multi-Omics to Wheat Resistance Types toInternational journal of molecular sciences · 2022Review
- tRNA-derived fragments from wheat are potentially involved in susceptibility to Fusarium head blight.BMC plant biology · 2022Article
12 more citing papers are in PubMed but not listed here.
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12 authors at 2 institutions in 3 countries.
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Abstract
Fusarium head blight, caused by Fusarium graminearum, is a devastating disease of wheat. We developed near-isogenic lines (NILs) differing in the two strongest known F. graminearum resistance quantitative trait loci (QTLs), Qfhs.ndsu-3BS (also known as resistance gene Fhb1) and Qfhs.ifa-5A, which are located on the short arm of chromosome 3B and on chromosome 5A, respectively. These NILs showing different levels of resistance were used to identify transcripts that are changed significantly in a QTL-specific manner in response to the pathogen and between mock-inoculated samples. After inoculation with F. graminearum spores, 16 transcripts showed a significantly different response for Fhb1 and 352 for Qfhs.ifa-5A. Notably, we identified a lipid transfer protein which is constitutively at least 50-fold more abundant in plants carrying the resistant allele of Qfhs.ifa-5A. In addition to this candidate gene associated with Qfhs.ifa-5A, we identified a uridine diphosphate (UDP)-glycosyltransferase gene, designated TaUGT12887, exhibiting a positive difference in response to the pathogen in lines harbouring both QTLs relative to lines carrying only the Qfhs.ifa-5A resistance allele, suggesting Fhb1 dependence of this transcript. Yet, this dependence was observed only in the NIL with already higher basal resistance. The complete cDNA of TaUGT12887 was reconstituted from available wheat genomic sequences, and a synthetic recoded gene was expressed in a toxin-sensitive strain of Saccharomyces cerevisiae. This gene conferred deoxynivalenol resistance, albeit much weaker than that observed with the previously characterized barley HvUGT13248.
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