ArticleMuscles, ligaments and tendons journal2012
Stem cell research and clinical development in tendon repair.
Article in Muscles, ligaments and tendons journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Anterior cruciate ligament reconstruction and return to sport activity: postural control as the key to success.International orthopaedics · 2015Trial
- Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.Stem cells international · 2025Article
- In Vitro Biocompatibility Assessment of Bioengineered PLA-Hydrogel Core-Shell Scaffolds with Mesenchymal Stromal Cells for Bone Regeneration.Journal of functional biomaterials · 2024Article
- Tendon Transection Healing Can Be Improved With Adipose-Derived Stem Cells Cultured With Growth Differentiation Factor 5 and Platelet-Derived Growth Factor.Hand (New York, N.Y.) · 2023Article
- Allogenic Perinatal Tissue for Musculoskeletal Regenerative Medicine Applications: A Systematic Review.Biomedicines · 2022Review
- The Pivotal Role of Stem Cells in Veterinary Regenerative Medicine and Tissue Engineering.Veterinary sciences · 2022Review
- Allogenic perinatal tissue for musculoskeletal regenerative medicine applications: a systematic review protocol.Journal of orthopaedic surgery and research · 2022Article
- Basic Research on Tendon Repair: Strategies, Evaluation, and Development.Frontiers in medicine · 2021Review
- Stem Cells in Veterinary Medicine-Current State and Treatment Options.Frontiers in veterinary science · 2020Review
- Regulation of the tenogenic gene expression in equine tenocyte-derived induced pluripotent stem cells by mechanical loading and Mohawk.Stem cell research · 2019Article
- Isolation and Characterization of Multipotent Turkey Tendon-Derived Stem Cells.Stem cells international · 2018Article
- iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review.Journal of advanced research · 2017Review
- Advances in the Use of Stem Cells in Veterinary Medicine: From Basic Research to Clinical Practice.Scientifica · 2016Review
- CORR® ORS Richard A. Brand Award for Outstanding Orthopaedic Research: Engineering flexor tendon repair with lubricant, cells, and cytokines in a canine model.Clinical orthopaedics and related research · 2014Article
- Tenogenically differentiated adipose-derived stem cells are effective in Achilles tendon repair in vivo.Journal of tissue engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in development and regeneration and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells (ESCs) which differentiate into all cell types, to adult stem cells (ASCs) which are responsible for tissue regeneration. Studies using animal models have shown promising results following cell therapy for induced injury in musculoskeletal system, including tendon healing, but the results can be variable. Alternative sources for cell therapy in tendon pathology may include ESCs, ASCs (bone marrow, adipose tissue or tendon derived stem cells) or induced pluripotent stem cells (iPSCs). While ethical and safety concerns currently forbid clinical application of ESCs and iPSCs, initial clinical trials with ASCs are promising.
Indexed as
Identifiers
23738298PMC3666527W1563699669What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.