Evidence map›Paper›PMID 23738251›Full record

ArticleMuscles, ligaments and tendons journal2011

Tenocytes, pro-inflammatory cytokines and leukocytes: a relationship?

Onays Al-Sadi, Gundula Schulze-Tanzil, Benjamin Kohl, Anke Lohan, Marion Lemke, Wolfgang Ertel, Thilo John

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Muscles, ligaments and tendons journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
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  6. Article
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Review
  14. Article
  15. Complement regulation in tenocytes under the influence of leukocytes in an indirect co-culture model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Article
  16. Innate tissue properties drive improved tendon healing in MRL/MpJ and harness cues that enhance behavior of canonical healing cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  17. Article
  18. Article
  19. Review: Emerging concepts in the pathogenesis of tendinopathy.The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland · 2017
    Review
  20. Tendon stem/progenitor cells regulate inflammation in tendon healingFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Onays Al-SadiDepartment for Orthopaedic, Trauma and Reconstructive Surgery, Charité-Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany.
Gundula Schulze-Tanzil
Benjamin Kohl
Anke Lohan
Marion Lemke
Wolfgang Ertel
Thilo John

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukocyte derived pro-inflammatory mediators could be involved in tendon healing and scar formation. Hence, the effect of autologous leukocytes (PBMCs, peripheral blood mononuclear cells and neutrophils) on primary rabbit Achilles tenocytes gene expression was tested in insert assisted co-cultures. Subsequently, tenocytes gene expression of extra-cellular matrix (ECM) components (type I collagen, decorin, fibronectin), the cell-ECM receptor β1-integrin, the angiogenic factor myodulin, ECM degrading matrix-metalloproteinase (MMP)1 and pro-inflammatory cytokines (interleukin [IL]-1β, tumour necrosis factor [TNFα] and IL-6) was analysed. The only significant effect of leukocytes on tenocytes ECM genes expression was a suppression of type I collagen by neutrophils combined with TNFα stimulation. The same effect could be observed analysing the β1-integrin and myodulin gene expression. However, PBMCs up-regulated significantly cytokine and MMP1 gene expression in tenocytes. These in vitro results suggest that mononuclear cells could present an exogenic stimulus for the induction of pro-inflammatory and catabolic mediators in tendon.

Indexed as

cytokinesIL-1βleukocytesmyodulintendonTNFα

Identifiers

PMID23738251
PMCPMC3666474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.