ReviewOxidative medicine and cellular longevity2013
Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants.
Review in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05936528 (The Effect of Lactoferrin in Improving Clinical Outcomes in ICU Patients), which is not on this map. Cited by 494 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Lactoferrin in Improving Clinical Outcomes in ICU Patients
Who cites it
494 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,331 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies.Psychopharmacology · 2025Pooled it
- Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis.Frontiers in immunology · 2025Pooled it
- Multivitamin use and risk of preeclampsia: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2022Pooled it
- Sigma-1 Receptor Mitigates Poly-GR-Associated Redox Dysregulation by Restoring NRF2/HO1 Signaling in C9orf72-Associated ALS.Neuromolecular medicine · 2026Article
- Construction of risk prediction models for psoriasis based on 45 dietary nutrients using machine learning and SHAP analysis.Asia Pacific journal of clinical nutrition · 2026Article
- Photobiomodulation therapy and postoperative recovery after abdominoplasty: a non-randomized pilot study.Lasers in medical science · 2026Article
- Do Oxidative Stress-Modified Exosomes Contribute to Infertility in Endometriosis?International journal of molecular sciences · 2026Review
- Exploring the medicinal potential of Bulbine latifolia (L.f.) Spreng.: a comprehensive review of phytochemicals and therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Impact of Lutein Supplementation on Liver Health, Oxidative Metabolism, Gut Microbiota, and Growth Performance in High-Fat Diet Fed Mice.Nutrients · 2026Article
- Pharmacological Significance and Phytochemical Diversity of the GenusPlants (Basel, Switzerland) · 2026Review
- A novel pH-responsive nanoreactor for pyroptosis induction: multifaceted ROS amplification drives potent immunotherapy against triple-negative breast cancer.Journal of nanobiotechnology · 2026Article
- Novelty stressor induces differential brain oxidative stress and antioxidant profiles between proactive and reactive stress coping styles.Scientific reports · 2026Article
- Synergistic Effect of Digoxin and Cisplatin on Redox Imbalance in HeLa Cells.Cell biochemistry and function · 2026Article
- Phytochemical fingerprinting, antioxidant activity and cytotoxic evaluation of marketed Thalictrum foliolosum (Pili Jadi) root against MCF-7 breast cancer cells.Scientific reports · 2026Article
- Silent Inflammation: A Critical Narrative Review of the Relationship Between Periodontal Disease and Psychosis-The Role of Oxidative Stress and Iatrogenic Comorbidities.Antioxidants (Basel, Switzerland) · 2026Review
- Oxidative Stress in Diabetic Cardiomyopathy: Molecular Mechanisms, Current Treatment and Therapeutic Potential of Plant Antioxidants.Antioxidants (Basel, Switzerland) · 2026Review
- QSAR Analysis of Lichen Depsides and Derivatives: Electronic Descriptors as Predictors of Antioxidant Activity via PLS-1.Antioxidants (Basel, Switzerland) · 2026Article
- Exploring the Biological Potency of Carotenoids Against Alzheimer's Disease: An Integrated Approach of Molecular Docking and Molecular Dynamics.Current issues in molecular biology · 2026Article
- Redox Regulation of the NLRP3 Inflammasome and its Implications for Immunization-related Neuroinflammation.Molecular neurobiology · 2026Review
434 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free radical damage is linked to formation of many degenerative diseases, including cancer, cardiovascular disease, cataracts, and aging. Excessive reactive oxygen species (ROS) formation can induce oxidative stress, leading to cell damage that can culminate in cell death. Therefore, cells have antioxidant networks to scavenge excessively produced ROS. The balance between the production and scavenging of ROS leads to homeostasis in general; however, the balance is somehow shifted towards the formation of free radicals, which results in accumulated cell damage in time. Antioxidants can attenuate the damaging effects of ROS in vitro and delay many events that contribute to cellular aging. The use of multivitamin/mineral supplements (MVMs) has grown rapidly over the past decades. Some recent studies demonstrated no effect of antioxidant therapy; sometimes the intake of antioxidants even increased mortality. Oxidative stress is damaging and beneficial for the organism, as some ROS are signaling molecules in cellular signaling pathways. Lowering the levels of oxidative stress by antioxidant supplements is not beneficial in such cases. The balance between ROS and antioxidants is optimal, as both extremes, oxidative and antioxidative stress, are damaging. Therefore, there is a need for accurate determination of individual's oxidative stress levels before prescribing the supplement antioxidants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.