ArticlePloS one2013
Dietary carbohydrates modulate Candida albicans biofilm development on the denture surface.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Voriconazole Activity AgainstMolecules (Basel, Switzerland) · 2026Article
- Chemical Elements and Thickness of Candida albicans Biofilm Induced by Glucose, Lactose, Protein, and Iron.European journal of dentistry · 2025Article
- Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway.Nature communications · 2025Article
- Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease.Journal of fungi (Basel, Switzerland) · 2025Review
- Sphingosine 1-phosphate receptor 1signaling in macrophages reduces atherosclerosis in LDL receptor-deficient mice.JCI insight · 2024Article
- Benzyldimethyldodecyl Ammonium Chloride-Doped Denture-Based Resin: Impact on Strength, Surface Properties, Antifungal Activities, and In Silico Molecular Docking Analysis.Journal of functional biomaterials · 2024Article
- Syzygium aromaticum essential oil and its major constituents: Assessment of activity against Candida spp. and toxicity.PloS one · 2024Article
- Review
- Itraconazole-Loaded Ufasomes: Evaluation, Characterization, and Anti-Fungal Activity againstPharmaceutics · 2022Article
- Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.International journal of molecular sciences · 2022Review
- Therapeutic Effect of Green Synthesized Silver Nanoparticles UsingMolecules (Basel, Switzerland) · 2022Article
- Phloretin inhibited the pathogenicity and virulence factors againstBioengineered · 2021Article
- Antimicrobial and Antibiofilm Effect of ε-Polylysine againstFoods (Basel, Switzerland) · 2021Article
- Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management.Journal of fungi (Basel, Switzerland) · 2021Review
- Yeast-Host Interactions:Frontiers in pharmacology · 2021Article
- The Transcription Factor Stp2 Is Important forFrontiers in microbiology · 2020Article
- Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis.Scientific reports · 2019Article
- Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids.Nutrients · 2019Article
- Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity ofInternational journal of dentistry · 2018Article
- Biophysical Effects of a Polymeric Biosurfactant in Candida krusei and Candida albicans Cells.Mycopathologia · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate whether dietary carbohydrates can modulate the development of Candida albicans biofilms on the denture material surface. Poly (methyl methacrylate) acrylic resin discs were fabricated and had their surface roughness measured. Biofilms of C. albicans ATCC 90028 were developed on saliva-coated specimens in culture medium without (control) or with carbohydrate supplementation by starch, starch+sucrose, glucose, or sucrose for 72 h. The cell count, metabolic activity, biovolume, average thickness, and roughness coefficient were evaluated at the adhesion phase (1.5 h) and after 24, 48, and 72 h. The secretion of proteinases and phospholipases, cell surface energy, and production of extra/intracellular polysaccharides were analyzed after 72 h of biofilm development. Data were analyzed by one- and two-way ANOVA followed by Tukey's test at 5% significance level. In the early stages of colonization (adhesion and 24 h), the glucose group showed the highest cell counts and metabolic activity among the groups (p<0.05). After maturation (48 and 72 h), biofilms exposed to glucose, sucrose, or starch+sucrose showed higher cell counts and metabolic activity than the control and starch groups (p<0.001). Compared to the control group, biofilms developed on starch or starch+sucrose had more proteinase activity (p<0.001), whereas biofilms developed on glucose or sucrose had more phospholipase activity (p<0.05). Exposure to starch+sucrose increased the production of extracellular and intracellular polysaccharides (p<0.05). Biofilms developed on starch or without carbohydrate supplementation presented cells with more hydrophobic behavior compared to the other groups. Confocal images showed hyphae forms on biofilms exposed to starch or starch+sucrose. Within the conditions studied, it can be concluded that dietary carbohydrates can modulate biofilm development on the denture surface by affecting virulence factors and structural features.
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Registered trials
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