ArticlePloS one2013
Gender disparity between cutaneous and non-cutaneous manifestations of Lyme borreliosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Characteristics and Clinical Outcomes of Lyme Arthritis: A Retrospective Study.Open forum infectious diseases · 2026Article
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
- Clinical Manifestations of Lyme Borreliosis in Europe: Burden of Lyme Disease Study (BOLD), 2021-2022.Pathogens (Basel, Switzerland) · 2026Article
- Sex and menopause-based differences in presentation of early Lyme disease: A prospective cohort study.Clinical and experimental medicine · 2026Article
- Aberrant T-cell phenotypes in a cohort of patients with post-treatment Lyme disease.Frontiers in immunology · 2025Article
- Associations of Atrioventricular Blocks and Other Arrhythmias in Patients with Lyme Carditis: A Systematic Review and Meta-Analysis.Journal of cardiovascular development and disease · 2024Review
- Epidemiology of Lyme Borreliosis in France in Primary Care and Hospital Settings, 2010-2019.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023Article
- Case presentation and management of Lyme disease patients: a 9-year retrospective analysis in France.Frontiers in medicine · 2023Article
- Sex and Gender Differences in Bacterial Infections.Infection and immunity · 2022Review
- Borrelial lymphocytoma.Wiener klinische Wochenschrift · 2022Review
- Risk factors for Lyme disease stage and manifestation using electronic health records.BMC infectious diseases · 2021Article
- Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients.Journal of internal medicine · 2021Article
- Comparison of Lyme Disease in the United States and Europe.Emerging infectious diseases · 2021Review
- Lyme Neuroborreliosis in Children.Brain sciences · 2021Review
- Lyme Disease among Patients at an Ambulatory Unit in a Highly Endemic Country: Lithuania.Medicina (Kaunas, Lithuania) · 2021Article
- Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease.PloS one · 2021Article
- Patients with Erythema Migrans: Characterizing the Impact of Initiation of Antibiotic Therapy Prior to Study Enrollment.Antimicrobial agents and chemotherapy · 2020Article
- Specific composition of polyphenolic compounds with fatty acids as an approach in helping to reduce spirochete burden in Lyme disease:Therapeutic advances in chronic disease · 2020Article
- Generality of Post-Antimicrobial Treatment Persistence ofInfection and immunity · 2019Article
- Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.International journal of general medicine · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous manifestations of Lyme borreliosis in Europe include erythema migrans (EM) and acrodermatitis chronica atrophicans (ACA); the most common non-cutaneous manifestations are Lyme neuroborreliosis (LNB) and Lyme arthritis. The purpose of this study was to evaluate the gender distribution of patients with these clinical manifestations of Lyme borreliosis. Data on gender were obtained from the clinical records of patients with Lyme borreliosis aged ≥15 years who had been evaluated at the University Medical Center Ljubljana, Ljubljana, Slovenia. Among 10,539 patients diagnosed with EM, 6,245 (59.3%) were female and among 506 ACA patients 347 (68.6%) were female. In contrast, among the 60 patients with Lyme arthritis only 15 (25%) were female (p<0.0001 for the comparison of gender with EM or ACA) and among the 130 patients with LNB only 51 (39.2%) were females (p<0.0001for the comparison of gender with EM or ACA). Although the proportion that was female in the LNB group was greater than that of patients with Lyme arthritis, this difference did not reach statistical significance (p = 0.10). Although older individuals are more likely to be female in the general Slovenian population, the age of patients with cutaneous versus non-cutaneous manifestations was not the explanation for the observed differences in gender. In conclusion, patients with cutaneous manifestations of Lyme borreliosis were predominantly female, whereas those with non-cutaneous manifestations were predominantly male. This provocative finding is unexplained but may have direct relevance to the pathogenesis of Lyme borreliosis.
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