ArticlePloS one2013
MstX and a putative potassium channel facilitate biofilm formation in Bacillus subtilis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms.PLoS computational biology · 2025Article
- Bioprospecting of extremophilic perchlorate-reducing bacteria: report of promising Bacillus spp. isolated from sediments of the bay of Cartagena, Colombia.Biodegradation · 2024Article
- Electrical Impedance Spectroscopy with Bacterial Biofilms: Neuronal-like Behavior.Nano letters · 2024Article
- Effects of genetic and environmental variables on biofilm development dynamics inIranian journal of microbiology · 2023Article
- Efficient Inhibition of Bacterial Biofilm Through Interference of Protein-Protein Interaction of Master Regulator Proteins: a Proof of Concept Study with SinR- SinI Complex of Bacillus subtilis.Applied biochemistry and biotechnology · 2023Article
- Electrochemical potential enables dormant spores to integrate environmental signals.Science (New York, N.Y.) · 2022Article
- Cellular Modifications of Rhodococci Exposed to Separate and Combined Effects of Pharmaceutical Pollutants.Microorganisms · 2022Article
- Article
- Unappreciated Roles for KTrends in microbiology · 2021Review
- Phospholipids and Fatty Acids Affect the Colonization of Urological Catheters byInternational journal of molecular sciences · 2021Article
- IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria.Cell systems · 2021Review
- Toward Bacterial Bioelectric Signal Transduction.Bioelectricity · 2021Article
- The Many Roles of the Bacterial Second Messenger Cyclic di-AMP in Adapting to Stress Cues.Journal of bacteriology · 2020Review
- Encoding Membrane-Potential-Based Memory within a Microbial Community.Cell systems · 2020Article
- A channel profile report of the unusual KThe Journal of general physiology · 2019Article
- Conformational Dynamics Govern the Free-Energy Landscape of a Membrane-Interacting Protein.ACS omega · 2018Article
- Signal Percolation within a Bacterial Community.Cell systems · 2018Article
- Compatible Solute Synthesis and Import by the Moderate HalophileFrontiers in microbiology · 2018Article
- Habits of Highly Effective Biofilms: Ion Signaling.Molecular cell · 2017Article
- Differences in Gene Expression Profiles between Early and Late Isolates in Monospecies Achromobacter Biofilm.Pathogens (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilms constitute the predominant form of microbial life and a potent reservoir for innate antibiotic resistance in systemic infections. In the spore-forming bacterium Bacillus subtilis, the transition from a planktonic to sessile state is mediated by mutually exclusive regulatory pathways controlling the expression of genes required for flagellum or biofilm formation. Here, we identify mstX and yugO as novel regulators of biofilm formation in B. subtilis. We show that expression of mstX and the downstream putative K+ efflux channel, yugO, is necessary for biofilm development in B. subtilis, and that overexpression of mstX induces biofilm assembly. Transcription of the mstX-yugO operon is under the negative regulation of SinR, a transcription factor that governs the switch between planktonic and sessile states. Furthermore, mstX regulates the activity of Spo0A through a positive autoregulatory loop involving KinC, a histidine kinase that is activated by potassium leakage. The addition of potassium abrogated mstX-mediated biofilm formation. Our findings expand the role of Spo0A and potassium homeostasis in the regulation of bacterial development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.