ArticleExperimental and therapeutic medicine2013
Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass.
Article in Experimental and therapeutic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Early Sustained High-Level HMGB1 and Poor Outcomes After Neonatal Congenital Cardiac Surgery with Cardiopulmonary Bypass.Pediatric cardiology · 2026Article
- Elevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an increased propensity for perioperative cerebrovascular events.Frontiers in medicine · 2025Article
- Article
- Weighted gene co-expression identification of CDKN1A as a hub inflammation gene following cardiopulmonary bypass in children with congenital heart disease.Frontiers in surgery · 2022Article
- Postoperative Neutrophil-to-Lymphocyte Ratio Is Associated with Mortality in Adult Patients After Cardiopulmonary Bypass Surgery: A Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The role and mechanism of the annexin A1 peptide Ac2-26 in rats with cardiopulmonary bypass lung injury.Basic & clinical pharmacology & toxicology · 2021Article
- HMGB-1/RAGE signaling inhibition by dioscin attenuates hippocampal neuron damage induced by oxygen-glucose deprivation/reperfusion.Experimental and therapeutic medicine · 2020Article
- Electroacupuncture Pretreatment Attenuates Acute Lung Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of HMGB1 Release in Rats After Cardiopulmonary Bypass.Shock (Augusta, Ga.) · 2018Article
- A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats.Journal of visualized experiments : JoVE · 2018Article
- Dexamethasone Preconditioning in Cardiac Procedures Reduces Decreased Antithrombin Activity and Is Associated to Beneficial Outcomes: Role of Endothelium.Frontiers in pharmacology · 2018Article
- cfDNA correlates with endothelial damage after cardiac surgery with prolonged cardiopulmonary bypass and amplifies NETosis in an intracellular TLR9-independent manner.Scientific reports · 2017Article
- Platelets activation is associated with elevated plasma mitochondrial DNA during cardiopulmonary bypass.Journal of cardiothoracic surgery · 2016Article
- Markers of early atherosclerosis, oxidative stress and inflammation in patients with acromegaly.Pituitary · 2015Article
- Variation of perioperative plasma mitochondrial DNA correlate with peak inflammatory cytokines caused by cardiac surgery with cardiopulmonary bypass.Journal of cardiothoracic surgery · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High mobility group box 1 (HMGB1), which is released by activated immune cells and necrotic cells, has properties similar to those of pro-inflammatory cytokines. Cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted to observe the dynamic changes of HMGB1 and tumor necrosis factor (TNF)-α levels during CPB and to analyze their clinical significance. A total of 78 cases of American Society of Anesthesiologists (ASA) grade II-IV undergoing elective valve replacement under CPB were included in this study. Blood and urine samples were collected after anesthesia prior to surgery (T1), before aortic cross-clamping (T2), after CPB (T3) and on the first day after surgery (T4), as well as the second (T5) and third (T6) day after surgery for determination of the levels of HMGB1, TNF-α, alanine aminotransferase (ALT), creatinine (Cr), blood urea nitrogen (BUN), N-acetyl-β-D-glucosamidase (NAG) and β2-microglobulin (β2-MG). Results revealed that: i) the serum levels of HMGB1 elevated as early as T1, increased until reaching a peak at T3, then decreased to a lower level at T4; ii) the serum level of TNF-α was low at T1, gradually increased in a similar manner to HMGB1, then decreased following CPB and reached the lowest point at T5; and iii) the levels of HMGB1 were positively correlated with serum TNF-α and serum ALT at T3. In conclusion, HMGB1 levels may be used as an indicator of inflammation and may be a novel target for controlling inflammation during CPB. The optimal treatment time is T3 (after CPB).
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