ArticleEvidence-based complementary and alternative medicine : eCAM2013
A network pharmacology approach to evaluating the efficacy of chinese medicine using genome-wide transcriptional expression data.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
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- GC-MS and Network Pharmacology Analysis of the Ayurvedic Fermented Medicine, Chandanasava, Against Chronic Kidney and Cardiovascular Diseases.Applied biochemistry and biotechnology · 2023Article
- Network Pharmacology Approach for Medicinal Plants: Review and Assessment.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Bipartite graph search optimization for type II diabetes mellitus Jamu formulation using branch and bound algorithm.Frontiers in pharmacology · 2022Article
- Exploration of the Molecular Mechanism of Danzhi Xiaoyao Powder in Endometrial Cancer through Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Investigation of cardiovascular protective effect of Shenmai injection by network pharmacology and pharmacological evaluation.BMC complementary medicine and therapies · 2020Article
- Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway.EXCLI journal · 2020Article
- Shenmai Injection Improves Energy Metabolism in Patients With Heart Failure: A Randomized Controlled Trial.Frontiers in pharmacology · 2020Article
- Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks.Scientific reports · 2019Article
- A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Protective mechanism of shenmai on myocardial ischemia-reperfusion through the energy metabolism pathway.American journal of translational research · 2019Article
- Uncovering Synergistic Mechanism of Chinese Herbal Medicine in the Treatment of Atrial Fibrillation with Obstructive Sleep Apnea Hypopnea Syndrome by Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Potential Root Foraging Strategy of Wheat (Frontiers in plant science · 2018Article
- Uncovering the Pharmacological Mechanism of Astragalus Salvia Compound on Pregnancy-Induced Hypertension Syndrome by a Network Pharmacology Approach.Scientific reports · 2017Article
- Evaluating the antidiabetic effects of Chinese herbal medicine: Xiao-Ke-An in 3T3-L1 cells and KKAy mice using both conventional and holistic omics approaches.BMC complementary and alternative medicine · 2015Article
- Comparative analysis of potassium deficiency-responsive transcriptomes in low potassium susceptible and tolerant wheat (Triticum aestivum L.).Scientific reports · 2015Article
- Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis.Chinese medicine · 2015Article
- Identifying roles of "Jun-Chen-Zuo-Shi" component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology.Chinese medicine · 2014Article
- A network study of chinese medicine xuesaitong injection to elucidate a complex mode of action with multicompound, multitarget, and multipathway.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The research of multicomponent drugs, such as in Chinese Medicine, on both mechanism dissection and drug discovery is challenging, especially the approaches to systematically evaluating the efficacy at a molecular level. Here, we presented a network pharmacology-based approach to evaluating the efficacy of multicomponent drugs by genome-wide transcriptional expression data and applied it to Shenmai injection (SHENMAI), a widely used Chinese Medicine composed of red ginseng (RG) and Radix Ophiopogonis (RO) in clinically treating myocardial ischemia (MI) diseases. The disease network, MI network in this case, was constructed by combining the protein-protein interactions (PPI) involved in the MI enriched pathways. The therapeutic efficacy of SHENMAI, RG, and RO was therefore evaluated by a network parameter, namely, network recovery index (NRI), which quantitatively evaluates the overall recovery rate in MI network. The NRI of SHENMAI, RG, and RO were 0.865, 0.425, and 0.271 respectively [corrected], which indicated SHENMAI exerts protective effects and the synergistic effect of RG and RO on treating myocardial ischemia disease. The successful application of SHENMAI implied that the proposed network pharmacology-based approach could help researchers to better evaluate a multicomponent drug on a systematic and molecular level.
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Registered trials
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