ReviewClinical & developmental immunology2013
Neonatal immune adaptation of the gut and its role during infections.
Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 110 citations in OpenAlex.
- The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Trial
- Ecology of protection: probiotic biogeography and sepsis prevention in the neonatal intestine.mBio · 2026Article
- Early growth restriction disrupts mice intestinal clock and homeostasis without being prevented by lactoferrin.Pediatric research · 2026Article
- Maternal-fetal dialogue and immunological programming: from fetal development to long-term health outcomes.Frontiers in oncology · 2026Review
- Transplacental Antimicrobial Antibodies and Childhood Asthma: Maternal Nativity as an Upstream Factor.Allergy · 2026Article
- Probiotic biogeography and sepsis prevention in the neonatal intestine.bioRxiv : the preprint server for biology · 2025Article
- Oxytocin Intervention Mitigates Pathological and Behavioral Impairments in APP/PS1 Mice Subjected to Early Social Isolation.CNS neuroscience & therapeutics · 2025Article
- Article
- Integrating Exposures and Multi-Omics in the Boston Birth Cohort to Elucidate Immune Development across the Life Course: Rationale and Study Design.Precision nutrition · 2025Article
- The Role of Breast Milk Cell-Free DNA in the Regulation of the Neonatal Immune Response.Nutrients · 2024Review
- Infant and adult human intestinal enteroids are morphologically and functionally distinct.mBio · 2024Article
- Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Pro-inflammatory T cells-derived cytokines enhance the maturation of the human fetal intestinal epithelial barrier.iScience · 2024Article
- Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.bioRxiv : the preprint server for biology · 2024Article
- Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age.Journal of translational medicine · 2023Article
- Group B Streptococcus Drives Major Transcriptomic Changes in the Colonic Epithelium.Infection and immunity · 2023Article
- Rapid bilateral pulmonary artery banding: A developmentally based proposal for the management of neonates with hypoplastic left heart.JTCVS open · 2023Article
- Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.Biomedical journal · 2023Article
- Host metabolome and faecal microbiome shows potential interactions impacted by age and weaning times in calves.Animal microbiome · 2023Article
- Effects ofNutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal tract is engaged in a relationship with a dense and complex microbial ecosystem, the microbiota. The establishment of this symbiosis is essential for host physiology, metabolism, and immune homeostasis. Because newborns are essentially sterile, the first exposure to microorganisms and environmental endotoxins during the neonatal period is followed by a crucial sequence of active events leading to immune tolerance and homeostasis. Contact with potent immunostimulatory molecules starts immediately at birth, and the discrimination between commensal bacteria and invading pathogens is essential to avoid an inappropriate immune stimulation and/or host infection. The dysregulation of these tight interactions between host and microbiota can be responsible for important health disorders, including inflammation and sepsis. This review summarizes the molecular events leading to the establishment of postnatal immune tolerance and how pathogens can avoid host immunity and induce neonatal infections and sepsis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.