ReviewPLoS genetics2013
Global properties and functional complexity of human gene regulatory variation.
Review in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis.Oncotarget · 2017Pooled it
- Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.PLoS genetics · 2014Pooled it
- Integrating linkage mapping and GWAS reveals novel genetic architecture of seed weight in soybean (Frontiers in plant science · 2025Article
- Connecting intermediate phenotypes to disease using multi-omics in heart failure.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Connecting intermediate phenotypes to disease using multi-omics in heart failure.medRxiv : the preprint server for health sciences · 2024Article
- Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.PLoS genetics · 2021Article
- Post-GWAS functional studies reveal an RA-associated CD40-induced NF-kB signal transduction and transcriptional regulation network targeted by class II HDAC inhibitors.Human molecular genetics · 2021Article
- Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits.Genetics, selection, evolution : GSE · 2021Article
- Robust partitioning of microRNA targets from downstream regulatory changes.Nucleic acids research · 2020Article
- Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer.EBioMedicine · 2019Article
- Bayesian multivariate reanalysis of large genetic studies identifies many new associations.PLoS genetics · 2019Article
- Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Association betweenBioscience reports · 2017Article
- Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.Nature communications · 2017Article
- Time-dependent genetic effects on gene expression implicate aging processes.Genome research · 2017Article
- The Genetic Architecture of Gene Expression in Peripheral Blood.American journal of human genetics · 2017Article
- Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.Nature genetics · 2017Article
- Association of insulin-like growth factor I gene polymorphisms with the risk of osteoporosis in a Chinese population.International journal of clinical and experimental pathology · 2017Article
- A potential role for genome structure in the translation of mechanical force during immune cell development.Nucleus (Austin, Tex.) · 2016Review
- Transethnic Genetic-Correlation Estimates from Summary Statistics.American journal of human genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Identification and functional interpretation of gene regulatory variants is a major focus of modern genomics. The application of genetic mapping to molecular and cellular traits has enabled the detection of regulatory variation on genome-wide scales and revealed an enormous diversity of regulatory architecture in humans and other species. In this review I summarise the insights gained and questions raised by a decade of genetic mapping of gene expression variation. I discuss recent extensions of this approach using alternative molecular phenotypes that have revealed some of the biological mechanisms that drive gene expression variation between individuals. Finally, I highlight outstanding problems and future directions for development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.