Evidence map›Paper›PMID 23737704›Full record

ReviewTheScientificWorldJournal2013

Biomarkers of periodontal tissue remodeling during orthodontic tooth movement in mice and men: overview and clinical relevance.

Fabrizia d'Apuzzo, Salvatore Cappabianca, Domenico Ciavarella, Angela Monsurrò, Armando Silvestrini-Biavati, Letizia Perillo

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02868554 (Orthodontic Tooth Movement With Accelerated Invisalign Therapy Using Acceledent Aura), which is not on this map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02868554 nacompletednot on this mapstarted 2016, after this paper: background citation

Orthodontic Tooth Movement With Accelerated Invisalign Therapy Using Acceledent Aura: A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2016 to 2019Enrolled34ConditionsMalocclusionArmsAcceleDent Aura, Accelerated Invisalign therapy
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.Orthodontics & craniofacial research · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Fabrizia d'ApuzzoDepartment of Orthodontics, Second University of Naples, Naples, Italy.
Salvatore Cappabianca
Domenico Ciavarella
Angela Monsurrò
Armando Silvestrini-Biavati
Letizia Perillo
University of Campania "Luigi Vanvitelli" · ITUniversity of Foggia · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, periodontal ligament changes, and vascular and neural responses are proposed. Citations to potentially published trials were conducted by searching PubMed, Cochrane databases, and scientific textbooks. Additionally, hand searching and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Selection criteria were as follows: animal models involving only mice and rats undergoing orthodontic treatment; collection of gingival crevicular fluid (GCF) as a noninvasively procedure for humans; no other simultaneous treatment that could affect experimental orthodontic movement. The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined.

Indexed as

AnimalsCytokinesHumansMacrophage Colony-Stimulating FactorMicePeriodontiumRANK LigandTooth MobilityTooth Movement TechniquesVascular Endothelial Growth Factor ACytokinesMacrophage Colony-Stimulating FactorRANK LigandVascular Endothelial Growth Factor A

Identifiers

PMID23737704
PMCPMC3655650
OpenAlexW1997626287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.