ArticleCurrent oncology (Toronto, Ont.)2013
A comparison of patient knowledge of clinical trials and trialist priorities.
Article in Current oncology (Toronto, Ont.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- An Evaluation of Clinical Trial Multimedia to Support Hispanic Cancer Patients' Informational and Decision-Making Needs.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021Trial
- Clinical Trial Perceptions Among Patients Enrolled in a Precision Oncology Protocol at an Appalachian-Serving Cancer Center.Psycho-oncology · 2026Article
- Attitudes and Willingness to Participate in Drug Clinical Trials Among Patients With Cancer: Multistage Qualitative Study.Journal of medical Internet research · 2026Article
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- Exploring patient-reported barriers to participating in proton therapy clinical trials.Technical innovations & patient support in radiation oncology · 2024Article
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- Development and Evaluation of the Clinical Trial HEalth Knowledge and Beliefs Scale (CHEKS).International journal of environmental research and public health · 2022Article
- Tailored Messages About Research Participation: Using an Interactive Information Aid to Improve Study Recruitment.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022Article
- Oncologic patients' misconceptions may impede enrollment into clinical trials: a cross-sectional study.BMC medical research methodology · 2022Article
- Are We Scared of Clinical Trials if Not Sufficiently Informed and Educated?Advances in medical education and practice · 2022Article
- Patients' knowledge about their involvement in clinical trials. A non-randomized controlled trial.Frontiers in medicine · 2022Article
- What Motivates You to Share? The Effect of Interactive Tailored Information Aids on Information Sharing about Clinical Trials.Health communication · 2021Article
- Untangling interactivity's effects: The role of cognitive absorption, perceived visual informativeness, and cancer information overload.Patient education and counseling · 2021Article
- Clinical trials: Predictors of knowledge and attitudes towards participation.International journal of clinical practice · 2021Article
- Construction and Piloting of Attitude Towards Research Participation Scale for University Students.Psychology research and behavior management · 2021Article
- Participant perception, still a major challenge to clinical research in developing countries-A mixed methods study.PloS one · 2020Article
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- Ready to Make A Decision: A Model of Informational Aids to Improve Informed Participation in Clinical Trial Research.Journal of health communication · 2019Article
- Reducing attrition within clinical trials: The communication of retention and withdrawal within patient information leaflets.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecruitment to clinical trials remains poor, and patient knowledge of clinical trials is one barrier to recruitment. To identify knowledge deficits, we conducted and compared surveys measuring actual patient knowledge and clinical trialist priorities for patient knowledge.
methodsConsenting patients at a tertiary cancer centre answered a survey that included 2 opinion questions about their own knowledge and willingness to join a trial, and22 knowledge questions. Clinical researchers at the centre were asked 13 questions about the importance of various trials factors.
resultsOf 126 patients surveyed, 16% had joined a clinical trial, and 42% had a secondary school education or less. The mean correct response rate on the knowledge questions was 58%. Higher rates of correct responses were associated with lower age (p = 0.05), greater education (p = 0.006), prior trial participation (p < 0.001), agreement or strong agreement with perceived understanding of trials (p < 0.001), and willingness to join a clinical trial (p = 0.002). Trialists valued an understanding of the rationale for clinical trials and of randomization, placebo, and patient protection, but those particular topics were poorly understood by patients.
conclusionsPatient knowledge about clinical trials is poor, including knowledge of several concepts ranked important by clinical trialists. The findings suggest that when developing education interventions, emphasis should be placed on the topics most directly related to patient care, and factors such as age and education level should be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.